Severe CD4+ T‐cell lymphopenia is not observed in frequent plateletpheresis donors collected on the Fenwal Amicus
| العنوان: | Severe CD4+ T‐cell lymphopenia is not observed in frequent plateletpheresis donors collected on the Fenwal Amicus |
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| المؤلفون: | Mona Papari, Richard M. Kaufman, Rachel A. Gaufberg, Donna Neuberg, John M. Gansner, Jake Goldstein, Robert S. Makar |
| المصدر: | Transfusion. 59:2783-2787 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, Immunology, Blood count, Plateletpheresis, Blood Donors, 030204 cardiovascular system & hematology, Severity of Illness Index, Lower limit, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Lymphopenia, Humans, Immunology and Allergy, Medicine, Aged, Extramural, business.industry, Incidence, CD4+ T-cell lymphopenia, Equipment Design, Hematology, Blood collection, Middle Aged, Leukoreduction, Anesthesia, Female, business, 030215 immunology |
| الوصف: | Background In a recent study, we determined that 30% of frequent plateletpheresis donors collected using the Trima Accel Automated Blood Collection System (Terumo BCT) had a CD4+ T-cell count below 200 cells/μL. Whether CD4+ T-cell lymphopenia is associated with donation using other plateletpheresis instruments is unknown. Study design and methods We obtained blood samples from 30 current frequent Fenwal Amicus plateletpheresis donors. All participants had made 20 to 24 plateletpheresis donations in the most recent 365-day period, and all had previously donated over 50 times on the Fenwal Amicus instrument. Blood samples were analyzed to determine blood counts, including CD4+ and CD8+ counts. Results Of 30 study participants, none had a CD4+ count below 200 cells/μL. There was one participant with a CD4+ count between 200 and 300 cells/μL. This individual was over the age of 55 and had a history of more than 300 lifetime plateletpheresis sessions. One participant had a CD8+ count below the lower limit of normal (125 cells/μL) and a normal CD4+ count. Conclusion We did not detect severe CD4+ lymphopenia in frequent platelet donors undergoing plateletpheresis with the Fenwal Amicus. Since the Fenwal Amicus does not incorporate a leukoreduction system chamber, this finding supports the hypothesis that such chambers-found in the Trima Accel instrument-contribute to CD4+ lymphopenia in frequent platelet donors. |
| تدمد: | 1537-2995 0041-1132 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0574f897db6761abc86babe715ed392aTest https://doi.org/10.1111/trf.15441Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0574f897db6761abc86babe715ed392a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15372995 00411132 |
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