Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan
| العنوان: | Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan |
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| المؤلفون: | Antonia Demleitner, Paul Lingor, Katharina Götze, Benno Ikenberg, Thomas Thiele, Georg Mößmer, Benedikt Wiestler |
| المصدر: | Stroke and Vascular Neurology Stroke and Vascular Neurology, Vol, Iss |
| بيانات النشر: | BMJ Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, COVID-19 Vaccines, blood platelets, Case Report, complication, Argatroban, Sinus Thrombosis, Intracranial, ChAdOx1 nCoV-19, Medicine, Humans, Platelet, Platelet activation, Cerebral venous sinus thrombosis, RC346-429, Pathological, Sinus (anatomy), business.industry, SARS-CoV-2, Vaccination, COVID-19, medicine.disease, Magnetic Resonance Imaging, ddc, medicine.anatomical_structure, Female, Neurology. Diseases of the nervous system, Neurology (clinical), Radiology, haemorrhage, Cardiology and Cardiovascular Medicine, business, Complication, medicine.drug, MRI |
| الوصف: | Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial MRI was considered void of pathological findings, MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral haemorrhage. Diagnostic tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of VITT. Treatment with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2059-8696 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0559778e42cb8630e63615220a8dfba8Test http://europepmc.org/articles/PMC8717801Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0559778e42cb8630e63615220a8dfba8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20598696 |
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