A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction
| العنوان: | A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction |
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| المؤلفون: | Magdalena Bednarek-Jędrzejek, Barbara Dołęgowska, Ewa Kwiatkowska, Rafał Rzepka, Sebastian Kwiatkowski, Andrzej Torbé |
| المصدر: | PLoS ONE, Vol 11, Iss 10, p e0165060 (2016) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Placental growth factor, Embryology, Physiology, Angiogenesis, Maternal Health, Placenta, lcsh:Medicine, Intrauterine growth restriction, 030204 cardiovascular system & hematology, Cardiovascular Physiology, Pediatrics, Biochemistry, Tyrosine Kinases, Receptor tyrosine kinase, Pathogenesis, Placental Growth Factor, Endocrinology, Child Development, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Medicine and Health Sciences, lcsh:Science, reproductive and urinary physiology, Fetal Growth Retardation, 030219 obstetrics & reproductive medicine, Multidisciplinary, biology, Obstetrics and Gynecology, Enzymes, C-Reactive Protein, medicine.anatomical_structure, Pregnancy Trimester, Second, Female, Anatomy, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Child Growth, Inflammatory Diseases, Inflammation, Preeclampsia, Young Adult, 03 medical and health sciences, Diagnostic Medicine, Growth Factors, Internal medicine, medicine, Humans, Receptor, Fibroblast Growth Factor, Type 1, Placenta Growth Factor, Endocrine Physiology, Growth Restriction, Interleukin-6, lcsh:R, Reproductive System, Biology and Life Sciences, Proteins, medicine.disease, Pregnancy Complications, Enzymology, biology.protein, Women's Health, lcsh:Q, Protein Kinases, Biomarkers, Developmental Biology |
| الوصف: | Preeclampsia and intrauterine growth restriction are two separate disease entities that, according to numerous reports, share the same pathogenesis. In both, angiogenesis disorders and generalized inflammation are the dominant symptoms. In this study, we hypothesized that both diseases demonstrate the same profile in early preeclampsia, late preeclampsia, and intrauterine growth restriction patients, with the only difference being the degree of exacerbation of lesions. One hundred sixty-seven patients were enrolled in the study and divided into four groups: early preeclampsia, late preeclampsia, and intrauterine growth restriction groups, and one control group. Concentrations of the angiogenesis and inflammatory markers soluble fms-like tyrosine kinase receptor 1, placental growth factor, high-sensitivity C-reactive protein, and interleukin-6 were determined, and the behavior of these markers and correlations among them were studied. Higher concentrations of soluble fms-like tyrosine kinase receptor 1, high-sensitivity C-reactive protein, and interleukin-6 and a lower concentration of placental growth factor were observed in the study groups compared with the control group. No differences in concentrations of the studied markers were found among the study groups but significant correlations were observed. The higher values for the angiogenesis and inflammatory markers both in preeclampsia patients and patients with intrauterine growth restriction of placental origin compared with the control group suggest the existence of the same underlying disorders in the development of these pathologies. The observed mutual correlations for disordered angiogenesis and inflammatory markers are suggestive of a mutual relationship between these processes in the development of pathologies evolving secondary to placental ischemia. The same lesion profile was observed for both preeclampsia and 'placental' intrauterine growth restriction patients, which could be used in developing common diagnostic criteria for pregnant patients. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d0114e07a83fd82bbaf7eacd4e22f5Test https://doi.org/10.1371/journal.pone.0165060Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....04d0114e07a83fd82bbaf7eacd4e22f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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