Free and Bioavailable Vitamin D Levels of Patients with Type 1 Diabetes Mellitus and Association with Bone Metabolism

التفاصيل البيبلوغرافية
العنوان: Free and Bioavailable Vitamin D Levels of Patients with Type 1 Diabetes Mellitus and Association with Bone Metabolism
المؤلفون: Ceyda Dincer Yazan, Ali Yaman, Goncagul Haklar, Onder Sirikci, Oguzhan Deyneli
المساهمون: DİNÇER YAZAN C., Yaman A., HAKLAR G., ŞİRİKÇİ Ö., Deyneli O.
المصدر: J Diabetes Metab Disord
سنة النشر: 2022
مصطلحات موضوعية: Internal Diseases, D-BINDING PROTEIN, ENDOCRINOLOGY & METABOLISM, Endocrinology, Diabetes and Metabolism, Endocrinology and Metabolic Diseases, Sağlık Bilimleri, İç Hastalıkları, Clinical Medicine (MED), SERUM, Endocrinology, FRACTURES, Health Sciences, Internal Medicine, Klinik Tıp (MED), Internal Medicine Sciences, Klinik Tıp, Endocrine and Autonomic Systems, Bioavailable vitamin D, Life Sciences, WOMEN, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, Free vitamin D, Type 1 DM, Endokrinoloji ve Metabolizma Hastalıkları, ENDOKRİNOLOJİ VE METABOLİZMA, Medicine, MINERAL DENSITY, TURNOVER, HEALTH, Research Article, VDBP
الوصف: AIM: Vitamin D deficiency is known to be associated with metabolic bone diseases. The aim of this study is to evaluate vitamin D and calculated free and bioactive vitamin D levels of type 1 diabetic patients and to evaluate the association with bone turnover markers. METHOD: This cross-sectional study includes 60 patients admitted to endocrinology outpatient clinic with diagnosis of type 1 diabetes mellitus and 60 controls. Weight, height and waist circumference were recorded and blood samples were taken for measurement of 25-hydroxyvitamin D (25(OH)D), vitamin D binding protein (VDBP), osteocalcin, bone alkaline phosphatase (bone-ALP), c-telopeptide. Free and bioavailable vitamin D levels were calculated with formula. RESULTS: Vitamin D levels of type 1 diabetic patients were significantly higher (p = 0.01). Parathormone levels of the group with vitamin D level under 20 ng/ml was significantly higher (p = 0.029). VDBP levels were similar in both groups. Correlation analysis of free and bioavailable vitamin D level with osteocalcin, c-telopeptide, bone alkaline phosphatase revealed only a weak significant correlation between free vitamin D and osteocalcin (r = -0.201; p = 0.028). A negative correlation was determined between 25(OH)D and parathormone levels (r = -0.294; p
وصف الملف: application/pdf
اللغة: English
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e8fc8fe1bfeabdc6f137bf27275978Test
https://hdl.handle.net/11424/288694Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....03e8fc8fe1bfeabdc6f137bf27275978
قاعدة البيانات: OpenAIRE