Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation
| العنوان: | Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation |
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| المؤلفون: | Rianne Kok, Henning Tiemeier, Marian J. Bakermans-Kranenburg, Lorenza Dall' Aglio, Marinus H. van IJzendoorn, Jolien Rijlaarsdam, Rosa H. Mulder, Charlotte A.M. Cecil, Alexander Neumann, Janine F. Felix |
| المساهمون: | Child and Adolescent Psychiatry / Psychology, Pediatrics, Clinical Child and Family Studies, Epidemiology, Educational and Family Studies |
| المصدر: | Psychological Medicine, 52(13), 2481-2491. Cambridge University Press Psychological Medicine Dall'Aglio, L, Rijlaarsdam, J, Mulder, R H, Neumann, A, Felix, J F, Kok, R, Bakermans-Kranenburg, M J, van Ijzendoorn, M H, Tiemeier, H & Cecil, C A M 2022, ' Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation : a population-based prospective study in children ', Psychological Medicine, vol. 52, no. 13, pp. 2481-2491 . https://doi.org/10.1017/S0033291720004353Test |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | population-based sample, Candidate gene, Offspring, Population, Quantitative trait locus, Biology, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Epigenetics, mQTLs, education, Applied Psychology, 030304 developmental biology, EWAS, Genetics, child development, 0303 health sciences, education.field_of_study, DNA methylation, epigenetics, maternal sensitivity, dNaM, Psychiatry and Mental health, Maternal sensitivity, maternal care, Caregiving environment, 030217 neurology & neurosurgery |
| الوصف: | BackgroundExperimental work in animals has shown that DNA methylation (DNAm), an epigenetic mechanism regulating gene expression, is influenced by typical variation in maternal care. While emerging research in humans supports a similar association, studies to date have been limited to candidate gene and cross-sectional approaches, with a focus on extreme deviations in the caregiving environment.MethodsHere, we explored the prospective association between typical variation in maternal sensitivity and offspring epigenome-wide DNAm, in a population-based cohort of children (N = 235). Maternal sensitivity was observed when children were 3- and 4-years-old. DNAm, quantified with the Infinium 450 K array, was extracted at age 6 (whole blood). The influence of methylation quantitative trait loci (mQTLs), DNAm at birth (cord blood), and confounders (socioeconomic status, maternal psychopathology) was considered in follow-up analyses.ResultsGenome-wide significant associations between maternal sensitivity and offspring DNAm were observed at 13 regions (p < 1.06 × 10−07), but not at single sites. Follow-up analyses indicated that associations at these regions were in part related to genetic factors, confounders, and baseline DNAm levels at birth, as evidenced by the presence of mQTLs at five regions and estimate attenuations. Robust associations with maternal sensitivity were found at four regions, annotated to ZBTB22, TAPBP, ZBTB12, and DOCK4.ConclusionsThese findings provide novel leads into the relationship between typical variation in maternal caregiving and offspring DNAm in humans, highlighting robust regions of associations, previously implicated in psychological and developmental problems, immune functioning, and stress responses. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0033-2917 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0326a93c3723e155acc93c977117f2dcTest https://doi.org/10.1017/s0033291720004353Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0326a93c3723e155acc93c977117f2dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00332917 |
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