Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia
| العنوان: | Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia |
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| المؤلفون: | Sampada Kallol, Susana Contreras-Duarte, Jaime Gutiérrez, Andrea Leiva, Bárbara Fuenzalida, Lorena Carvajal, Christiane Albrecht, Valentina Pasten, Claudette Cantin |
| المصدر: | Fuenzalida, Bárbara; Cantin, Claudette; Kallol, Sampada; Carvajal, Lorena; Pastén, Valentina; Contreras-Duarte, Susana; Albrecht, Christiane; Gutierrez, Jaime; Leiva, Andrea (2020). Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia. Scientific Reports, 10(1), p. 5264. Nature Publishing Group 10.1038/s41598-020-61629-4 <http://dx.doi.org/10.1038/s41598-020-61629-4Test> Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein B, Placenta, lcsh:Medicine, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, lcsh:Science, 610 Medicine & health, Maternal-Fetal Exchange, Cells, Cultured, ATP Binding Cassette Transporter, Subfamily G, Member 1, Multidisciplinary, biology, medicine.diagnostic_test, Middle Aged, Fetal Blood, Trophoblasts, Cholesterol, medicine.anatomical_structure, ABCG1, embryonic structures, Female, lipids (amino acids, peptides, and proteins), ATP Binding Cassette Transporter 1, Adult, Endocrine reproductive disorders, medicine.medical_specialty, Lipoproteins, Hypercholesterolemia, Article, Young Adult, 03 medical and health sciences, Syncytiotrophoblast, Internal medicine, medicine, Humans, Triglycerides, Dyslipidaemias, Apolipoprotein A-I, business.industry, lcsh:R, Infant, Newborn, Trophoblast, nutritional and metabolic diseases, Biological Transport, Pregnancy Complications, 030104 developmental biology, Endocrinology, Receptors, LDL, chemistry, ABCA1, LDL receptor, biology.protein, 570 Life sciences, lcsh:Q, Lipid profile, business |
| الوصف: | Maternal physiological (MPH) or supraphysiological hypercholesterolaemia (MSPH) occurs during pregnancy. Cholesterol trafficking from maternal to foetal circulation requires the uptake of maternal LDL and HDL by syncytiotrophoblast and cholesterol efflux from this multinucleated tissue to ApoA-I and HDL. We aimed to determine the effects of MSPH on placental cholesterol trafficking. Placental tissue and primary human trophoblast (PHT) were isolated from pregnant women with total cholesterol |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.7892/boris.144146 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fc3917882ccfda77e4b41df9170240Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02fc3917882ccfda77e4b41df9170240 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.7892/boris.144146 |
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