The Tubulin Code in Mitosis and Cancer
| العنوان: | The Tubulin Code in Mitosis and Cancer |
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| المؤلفون: | Helder Maiato, Danilo Lopes |
| المساهمون: | Instituto de Investigação e Inovação em Saúde |
| المصدر: | Cells Cells, Vol 9, Iss 2356, p 2356 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Review, tubulin post-translational modifications, Microtubules, Chromosome segregation, 0302 clinical medicine, Cell Movement, Tubulin, Chromosome instability, Neoplasms, Mitosis / genetics, Neoplasms / etiology, Protein Isoforms, lcsh:QH301-705.5, Neoplasms / metabolism, Cell Movement / genetics, 0303 health sciences, biology, General Medicine, Cell biology, 030220 oncology & carcinogenesis, Disease Susceptibility, microtubule, Microtubules / metabolism, chromosomal instability, Context (language use), macromolecular substances, Spindle Apparatus, 03 medical and health sciences, Microtubule, Detyrosination, biochemistry, Humans, cancer, Neoplasm Invasiveness, Mitosis, 030304 developmental biology, Cytokinesis, Centrosome, mitosis, Neoplasms / pathology, Tubulin / metabolism, Centrosome / metabolism, Spindle apparatus, Tubulin / genetics, lcsh:Biology (General), Spindle Apparatus / metabolism, tubulin code, biology.protein, Protein Processing, Post-Translational |
| الوصف: | The "tubulin code" combines different a/ß-tubulin isotypes with several post-translational modifications (PTMs) to generate microtubule diversity in cells. During cell division, specific microtubule populations in the mitotic spindle are differentially modified, but only recently, the functional significance of the tubulin code, with particular emphasis on the role specified by tubulin PTMs, started to be elucidated. This is the case of a-tubulin detyrosination, which was shown to guide chromosomes during congression to the metaphase plate and allow the discrimination of mitotic errors, whose correction is required to prevent chromosomal instability-a hallmark of human cancers implicated in tumor evolution and metastasis. Although alterations in the expression of certain tubulin isotypes and associated PTMs have been reported in human cancers, it remains unclear whether and how the tubulin code has any functional implications for cancer cell properties. Here, we review the role of the tubulin code in chromosome segregation during mitosis and how it impacts cancer cell properties. In this context, we discuss the existence of an emerging "cancer tubulin code" and the respective implications for diagnostic, prognostic and therapeutic purposes. Danilo Lopes is a student of Programa de Pós-Graduação Ciência para o Desenvolvimento (PGCD) from Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal and recipient of a studentship (SFRH/BD/135077/2017) from Fundação para a Ciência e a Tecnologia of Portugal. Work in the laboratory of H.M. is funded by the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement No 681443). |
| وصف الملف: | application/pdf |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a10aacc345646ff952f29ff23861b1Test https://pubmed.ncbi.nlm.nih.gov/33114575Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02a10aacc345646ff952f29ff23861b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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