Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences
| العنوان: | Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences |
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| المؤلفون: | Carolyn L Powell, Angus M. Brown, Anna R Davidson |
| المصدر: | Biosensors, Vol 10, Iss 183, p 183 (2020) Biosensors |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Nervous system, lcsh:Biotechnology, Clinical Biochemistry, Review, Nervous System, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, astrocyte, Alzheimer Disease, Lactate dehydrogenase, lcsh:TP248.13-248.65, Extracellular fluid, neurone, medicine, Animals, Humans, Lactic Acid, Amyotrophic lateral sclerosis, glucose, Pathological, 030304 developmental biology, Monocarboxylate transporter, Neurons, 0303 health sciences, lactate, Glycogen, biology, Brain, lactate dehydrogenase, General Medicine, monocarboxylate transporter, medicine.disease, medicine.anatomical_structure, chemistry, nervous system, Astrocytes, glycogen, biology.protein, Neuroscience, Neuroglia, 030217 neurology & neurosurgery, Astrocyte, Signal Transduction |
| الوصف: | Whilst it is universally accepted that the energy support of the brain is glucose, the form in which the glucose is taken up by neurones is the topic of intense debate. In the last few decades, the concept of lactate shuttling between glial elements and neural elements has emerged in which the glial cells glycolytically metabolise glucose/glycogen to lactate, which is shuttled to the neural elements via the extracellular fluid. The process occurs during periods of compromised glucose availability where glycogen stored in astrocytes provides lactate to the neurones, and is an integral part of the formation of learning and memory where the energy intensive process of learning requires neuronal lactate uptake provided by astrocytes. More recently sleep, myelination and motor end plate integrity have been shown to involve lactate shuttling. The sequential aspect of lactate production in the astrocyte followed by transport to the neurones is vulnerable to interruption and it is reported that such disparate pathological conditions as Alzheimer’s disease, amyotrophic lateral sclerosis, depression and schizophrenia show disrupted lactate signalling between glial cells and neurones. |
| اللغة: | English |
| تدمد: | 2079-6374 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026ad93ddad0afaac3da49218d58ae41Test https://www.mdpi.com/2079-6374/10/11/183Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....026ad93ddad0afaac3da49218d58ae41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20796374 |
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