Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma
| العنوان: | Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma |
|---|---|
| المؤلفون: | Kosuke Higuchi, Yuzuru Ikehara, Tomomi Furihata, Tomokazu Sazuka, Nobushige Takeshita, Kentaro Okunushi, Yusuke Imamura, Tomohiko Ichikawa, Kazuyoshi Nakamura, Naohiko Anzai, Maihulan Maimaiti, Keisuke Ando, Yoshie Reien, Shinichi Sakamoto, Jun Matsushima |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Cell type, lcsh:Medicine, Large Neutral Amino Acid-Transporter 1, Article, Prognostic markers, Cell Movement, Renal cell carcinoma, Cell Line, Tumor, Biomarkers, Tumor, medicine, Carcinoma, Humans, Progression-free survival, lcsh:Science, Carcinoma, Renal Cell, Cell Proliferation, Retrospective Studies, Benzoxazoles, Multidisciplinary, Molecular medicine, business.industry, lcsh:R, Cancer, Middle Aged, Prognosis, medicine.disease, Kidney Neoplasms, Progression-Free Survival, Cell culture, Cancer research, Tyrosine, Immunohistochemistry, Female, lcsh:Q, Clinical pharmacology, business |
| الوصف: | Large neutral amino acid transporter 1 (LAT1, SLC7A5) is abundantly expressed in various types of cancer, and it has been thought to assist cancer progression through its activity for uptake of neutral amino acids. However, the roles of LAT1 in renal cell carcinoma (RCC) prognosis and treatment remain uncharacterized. Therefore, we first retrospectively examined the LAT1 expression profile and its associations with clinical factors in RCC tissues (n = 92). The results of immunohistochemistry showed that most of the tissues examined (92%) had cancer-associated LAT1 expression. Furthermore, the overall survival (OS) and progression-free survival (PFS) were shorter in patients with high LAT1 expression levels than in those with low LAT1 expression levels (P = 0.018 and 0.014, respectively), and these associations were further strengthened by the results of univariate and multivariate analyses. Next, we tested the effects of JPH203, which is a selective LAT1 inhibitor, on RCC-derived Caki-1 and ACHN cells. It was found that JPH203 inhibited the growth of these cell types in a dose-dependent manner. Moreover, JPH203 clearly suppressed their migration and invasion activities. Thus, our results show that LAT1 has a great potential to become not only a prognosis biomarker but also a therapeutic target in RCC clinical settings. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0255314b5a4a620c1347ee783e406097Test http://link.springer.com/article/10.1038/s41598-019-53397-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0255314b5a4a620c1347ee783e406097 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|