Iron promotes the clearance of α‐synuclein
| العنوان: | Iron promotes the clearance of α‐synuclein |
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| المؤلفون: | Qing-Zhang Tuo, Peng Lei |
| المصدر: | Journal of Neurochemistry. 155:117-119 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Iron, animal diseases, Hfe gene, Regulator, Biochemistry, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Autophagy, Animals, Hemochromatosis Protein, Alpha-synuclein, Chemistry, nutritional and metabolic diseases, Parkinson Disease, Metabolism, nervous system diseases, Cell biology, Kinetics, 030104 developmental biology, nervous system, Toxicity, alpha-Synuclein, α synuclein, 030217 neurology & neurosurgery, Homeostasis |
| الوصف: | Both elevated iron and α-synuclein (α-syn) aggregates are neuropathological hallmarks of Parkinson's disease (PD). It has been previously shown that iron promotes α-synuclein aggregation, and α-synuclein dysfunction impairs iron metabolism. In their latest work, Kim et al. have shown that the H63D variant of the homeostatic iron regulator (HFE) facilitates α-syn degradation via REDD1-mediated autophagy. Mice with the H63D variant of HFE were protected against α-syn toxicity. These results may shed light on recent clinical studies of PD using iron chelation therapy. |
| تدمد: | 1471-4159 0022-3042 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e60146c31c45b379f451b7bd53b555Test https://doi.org/10.1111/jnc.15130Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....01e60146c31c45b379f451b7bd53b555 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14714159 00223042 |
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