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// Zhichao Tong 1, * , Yang Liu 2, * , Bo Chen 1 , Liang Yan 3 and Dingjun Hao 3 1 Department of Bone Diesase and Bone Tumor, Hong Hui Hospital, Xi’an Jiaotong University College of Medicine, Shaanxi 710054, China 2 Department of Orthopaedics, Hong Hui Hospital, Xi’an Jiaotong University College of Medicine, Shaanxi 710054, China 3 Department of Spinal Surgery, Hong Hui Hospital, Xi’an Jiaotong University College of Medicine, Shaanxi 710054, China * These authors have contributed equally to this work and should be considered as co-first authors Correspondence to: Liang Yan, email: liangyanhonghui@163.com Dingjun Hao, email: dingjunhaohonghui@163.com Keywords: MMP-3, TIPM-3, osteoarthritis, polymorphisms Received: December 21, 2016 Accepted: March 08, 2017 Published: June 27, 2017 ABSTRACT Osteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between MMP-3 and TIMP-3 variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi’an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between MMP-3 and TIMP-3 single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis. The minor G allele of rs650108 was associated with OA risk in a recessive model ( p = 0.034, OR = 1.82, 95%CI = 1.04-3.18), while the minor A allele of rs715572 was associated with OA risk in a recessive model ( p = 0.030, OR = 1.88, 95%CI = 1.05-3.34). Thus a suggestive association was observed in a discovery case-control study between OA and two common SNPs, rs650108 in MMP-3 and rs715572 in TIMP-3 . |
