Molecular Pathogenesis of Hepatocellular Carcinoma
| العنوان: | Molecular Pathogenesis of Hepatocellular Carcinoma |
|---|---|
| المؤلفون: | Irene Oi-Lin Ng, Lo-Kong Chan, Regina Cheuk-Lam Lo, Daniel W.H. Ho |
| المصدر: | Liver Cancer. 5:290-302 |
| بيانات النشر: | S. Karger AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Tumor microenvironment, Hepatology, Recent Advances of Molecular Pathology on HCC: Review, Biology, medicine.disease, digestive system diseases, Metastasis, Pathogenesis, 03 medical and health sciences, 030104 developmental biology, Oncology, Cancer stem cell, Hepatocellular carcinoma, Immunology, microRNA, medicine, Cancer research, Epigenetics, Signal transduction |
| الوصف: | The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process involving the progressive accumulation of molecular alterations pinpointing different molecular and cellular events. The next-generation sequencing technology is facilitating the global and systematic evaluation of molecular landscapes in HCC. There is emerging evidence supporting the importance of cancer metabolism and tumor microenvironment in providing a favorable and supportive niche to expedite HCC development. Moreover, recent studies have identified distinct surface markers of cancer stem cell (CSC) in HCC, and they also put forward the profound involvement of altered signaling pathways and epigenetic modifications in CSCs, in addition to the concomitant drug resistance and metastasis. Taken together, multiple key genetic and non-genetic factors, as well as liver CSCs, result in the development and progression of HCC. |
| تدمد: | 1664-5553 2235-1795 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011b83e3e9d8c806839c5d351a7ea379Test https://doi.org/10.1159/000449340Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....011b83e3e9d8c806839c5d351a7ea379 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16645553 22351795 |
|---|