Rational diagnostic strategies for Lyme borreliosis in children and adolescents: recommendations by the Committee for Infectious Diseases and Vaccinations of the German Academy for Pediatrics and Adolescent Health
| العنوان: | Rational diagnostic strategies for Lyme borreliosis in children and adolescents: recommendations by the Committee for Infectious Diseases and Vaccinations of the German Academy for Pediatrics and Adolescent Health |
|---|---|
| المؤلفون: | V. Fingerle, M. Kinet, R. Klein, Peter Bartmann, Hans-Iko Huppertz, G. C. Korenke, H. J. Nentwich, Ulrich Heininger |
| المصدر: | European Journal of Pediatrics |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Adolescent, Lymphocyte proliferation, Recommendations, Lyme Arthritis, Lyme disease, Diagnosis, medicine, Animals, Humans, Lyme Neuroborreliosis, Pediatrics, Perinatology, and Child Health, Borrelia burgdorferi, Child, Children, Lyme borreliosis, Antigens, Bacterial, Arthritis, Infectious, Lyme Disease, Ixodes, biology, Neuroborreliosis, business.industry, Lyme arthritis, biology.organism_classification, medicine.disease, Pediatrics, Perinatology and Child Health, Erythema chronicum migrans, Erythema Chronicum Migrans, Original Article, medicine.symptom, business |
| الوصف: | The varying clinical manifestations of Lyme borreliosis, transmitted by Ixodes ricinus and caused by Borrelia burgdorferi, frequently pose diagnostic problems. Diagnostic strategies vary between early and late disease manifestations and usually include serological methods. Erythema migrans is pathognomonic and does not require any further laboratory investigations. In contrast, the diagnosis of neuroborreliosis requires the assessment of serum and cerebrospinal fluid. Lyme arthritis is diagnosed in the presence of newly recognized arthritis and high-titer serum IgG antibodies against B. burgdorferi. The committee concludes the following recommendations: Borrelial serology should only be ordered in case of well-founded clinical suspicion for Lyme borreliosis, i.e., manifestations compatible with the diagnosis. Tests for borrelial genomic sequences in ticks or lymphocyte proliferation assays should not be ordered. When results of such tests or of serological investigations that were not indicated are available, they should not influence therapeutic decisions. Laboratories should be cautious when interpreting results of serological tests and abstain from giving therapeutic recommendations and from proposing retesting after some time without intimate knowledge of patient's history and disease manifestations. |
| تدمد: | 1432-1076 0340-6199 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d98efe988aded0b3112617fcd9479cTest https://doi.org/10.1007/s00431-012-1779-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....00d98efe988aded0b3112617fcd9479c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321076 03406199 |
|---|