New polyphenolic glycosides from the stems of Caesalpinia cucullata and their inhibitory effect on methicillin-resistant Staphylococcus aureus with different ways

التفاصيل البيبلوغرافية
العنوان: New polyphenolic glycosides from the stems of Caesalpinia cucullata and their inhibitory effect on methicillin-resistant Staphylococcus aureus with different ways
المؤلفون: Wenhua, Jing, Dandan, Guo, Zunxi, Ning, Ye, Yang, Ting, Liu, Miao, Wang, Huiyuan, Gao
المصدر: Bioorganic Chemistry. 129:106193
بيانات النشر: Elsevier BV, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Caesalpinia, Organic Chemistry, Drug Discovery, Glycosides, Microbial Sensitivity Tests, Molecular Biology, Biochemistry, Anti-Bacterial Agents
الوصف: Anti-virulence strategy represents an emerging alternative strategy in the war against increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) due to its milder selection pressure on bacterial resistance. Sortase A (SrtA), as an important virulence factor, is a membrane-localized cysteine transpeptidase which anchors cell surface proteins to the cell wall. Natural products in medicinal plants are the source of targeting bacterial virulence factors. Here, we found polyphenolic glycosides (1-15), including thirteen new derivatives isolated from the stems of Caesalpinia cucullata, exhibited weak to moderate SrtA inhibitory activity without affecting the growth of MRSA, and compound 7 (53.7 % inhibition at 100 μM) was superior to the positive control curcumin. Meanwhile, compounds 2, 4 and 8 could effectively reduce the dose of ceftiofur in combination in vitro with fractional inhibitory concentration index (FICI) ranging from 0.188 to 0.375, which meant polyphenolic glycosides have got antibacterial activity with different ways. Here, we reported all new compounds structures determined by spectroscopy methods and their antibacterial activities, together, the relationship between structures with the inhibitory efficiency. The results indicated that polyphenolic glycosides could be used as promising therapeutic agents to prevent resistance development for S. aureus infections.
تدمد: 0045-2068
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ac28e5fa67625afa7446b8073d361bTest
https://doi.org/10.1016/j.bioorg.2022.106193Test
حقوق: CLOSED
رقم الانضمام: edsair.doi.dedup.....00ac28e5fa67625afa7446b8073d361b
قاعدة البيانات: OpenAIRE