Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass
| العنوان: | Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass |
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| المؤلفون: | Caroline Ewertsen, Julie Abildgaard, Michael Bzorek, Carsten Thomsen, Thomas Wagner, Bente Klarlund Pedersen, Birgitte Lindegaard, Elaf Al-Saoudi, Thorkil Ploug, Anette Tønnes Pedersen |
| المصدر: | Abildgaard, J, Ploug, T, Al-Saoudi, E, Wagner, T, Thomsen, C, Ewertsen, C, Bzorek, M, Pedersen, B K, Pedersen, A T & Lindegaard, B 2021, ' Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass ', Scientific Reports, vol. 11, no. 1, 14750 . https://doi.org/10.1038/s41598-021-94189-2Test Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, medicine.medical_specialty, Science, Peroxisome Proliferator-Activated Receptors, Adipose tissue, 030209 endocrinology & metabolism, Inflammation, Context (language use), Intra-Abdominal Fat, Article, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Fibrosis, Internal medicine, medicine, Body Fat Distribution, Humans, Insulin, Metabolic Syndrome, Multidisciplinary, Molecular medicine, business.industry, Hypogonadism, Estrogen Receptor alpha, nutritional and metabolic diseases, Middle Aged, Hypoxia (medical), medicine.disease, Subcutaneous Fat, Abdominal, Menopause, Phenotype, 030104 developmental biology, Endocrinology, Risk factors, Medicine, Female, Pre-diabetes, Insulin Resistance, medicine.symptom, Adipocyte hypertrophy, business |
| الوصف: | Menopause is associated with a redistribution of adipose tissue towards central adiposity, known to cause insulin resistance. In this cross-sectional study of 33 women between 45 and 60 years, we assessed adipose tissue inflammation and morphology in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) across menopause and related this to menopausal differences in adipose tissue distribution and insulin resistance. We collected paired SAT and VAT biopsies from all women and combined this with anthropometric measurements and estimated whole-body insulin sensitivity. We found that menopause was associated with changes in adipose tissue phenotype related to metabolic dysfunction. In SAT, postmenopausal women showed adipocyte hypertrophy, increased inflammation, hypoxia and fibrosis. The postmenopausal changes in SAT was associated with increased visceral fat accumulation. In VAT, menopause was associated with adipocyte hypertrophy, immune cell infiltration and fibrosis. The postmenopausal changes in VAT phenotype was associated with decreased insulin sensitivity. Based on these findings we suggest, that menopause is associated with changes in adipose tissue phenotype related to metabolic dysfunction in both SAT and VAT. Whereas increased SAT inflammation in the context of menopause is associated with VAT accumulation, VAT morphology is related to insulin resistance. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006814f00fc37c2e57f606ca9e9b3f32Test https://doi.org/10.1038/s41598-021-94189-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....006814f00fc37c2e57f606ca9e9b3f32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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