Global longitudinal strain assessment in long-term survivors of childhood acute lymphoblastic leukemia
| العنوان: | Global longitudinal strain assessment in long-term survivors of childhood acute lymphoblastic leukemia |
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| المؤلفون: | R Gonzalez-Manzanares, C Pericet-Rodriguez, A Fernandez-Ruiz, C Fernandez-Aviles, G Heredia-Campos, A Resua-Collazo, J C Castillo-Dominguez |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background The role of global longitudinal strain (GLS) in the long-term cardiac evaluation of childhood acute lymphoblastic leukemia (ALL) survivors is not clearly defined. Purpose To assess the prevalence of subclinical left ventricular systolic dysfunction (SLVD) in long-term survivors of ALL. We also aimed to compare echocardiographic measurements with a control group. Methods Patients Results Of the 90 survivors included (37.8% female, time from diagnosis 18 [11–26] years), 24 (26.6%) had SLVD. Left ventricular systolic but not diastolic measurements were reduced compared to the control group (Table 1). Predictors of GLS in the survivors were smoking (p=0.004) and history of hematopoietic stem-cell transplantation (p=0.042) (Table 2). Conclusions Over ¼ of childhood ALL survivors had abnormal GLS values after a median follow-up of 18 years. Left-ventricular systolic parameters were reduced compared to a control group. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Sociedad Española de Cardiología. Sociedad Andaluza de Cardiología. |
| تدمد: | 1522-9645 0195-668X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::fdb6604890293de2fb4a2f00896ecdadTest https://doi.org/10.1093/eurheartj/ehac544.014Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........fdb6604890293de2fb4a2f00896ecdad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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