Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group
| العنوان: | Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group |
|---|---|
| المؤلفون: | K. Koumaravelou, Rajagopal Krishnamoorthy, Wahid Boukouaci, M.C. Abbadi, S. Salah, M. Gharnaout, M. Ghaffor, Manuel Brun, H. Djidjik, Ryad Tamouza, A. Benyounes, Dominique Charron, R. Djidjik |
| المصدر: | Tissue Antigens. 71:160-164 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | House dust mite, NOS1, Immunology, General Medicine, Biology, Endothelial NOS, medicine.disease, biology.organism_classification, Biochemistry, Nitric oxide, Nitric oxide synthase, chemistry.chemical_compound, chemistry, Genotype, Genetics, medicine, biology.protein, Immunology and Allergy, Allele, Asthma |
| الوصف: | Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin-dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 -84 G-->A and NOS3 -786 T-->C, 894 G-->T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the -786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the 'ab' genotype of the 27-bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders. |
| تدمد: | 1399-0039 0001-2815 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::fbb9a2400e354781b24459c4093ebf5eTest https://doi.org/10.1111/j.1399-0039.2007.00976.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........fbb9a2400e354781b24459c4093ebf5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990039 00012815 |
|---|