Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder
| العنوان: | Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder |
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| المؤلفون: | Sheida Zolfaghari, Natalia Lewandowski, Amelie Pelletier, Seyed Ali Naeimi, Jean-François Gagnon, Marina Brillon-Corbeil, Jacques Y. Montplaisir, Ronald B. Postuma |
| المصدر: | Journal of Parkinson's Disease. 12:927-933 |
| بيانات النشر: | IOS Press, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cellular and Molecular Neuroscience, Neurology (clinical) |
| الوصف: | Several studies have suggested that atherosclerotic diseases and diabetes may be risk factors for α-synucleinopathies. This prospective cohort study evaluated whether cardiovascular diseases and metabolic risk factors alter the rate or type of phenoconversion from idiopathic/isolated REM sleep behavior disorder (iRBD) to parkinsonism or dementia. Polysomnography-confirmed iRBD patients recruited between 2004 and 2020 were followed annually. Baseline history of cardiovascular disorders, hypertension, hypercholesterolemia, and diabetes were compared among patients who developed outcomes versus those who remained outcome-free. No atherosclerotic risk factors were associated with development of α-synucleinopathies. Patients with hypercholesterolemia were somewhat more likely to develop dementia with Lewy bodies rather than Parkinson’s disease. |
| تدمد: | 1877-718X 1877-7171 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f77a3be9e66ad430e5e8309740c1aaeaTest https://doi.org/10.3233/jpd-212984Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........f77a3be9e66ad430e5e8309740c1aaea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1877718X 18777171 |
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