Aconicatisulfonines A and B, Analgesic Zwitterionic C20-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii
| العنوان: | Aconicatisulfonines A and B, Analgesic Zwitterionic C20-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii |
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| المؤلفون: | Jiangong Shi, Shao Shuai, Chengbo Xu, Tiantai Zhang, Huan Xia, Yu-Zhuo Wu, Qing-Lan Guo |
| المصدر: | Organic Letters. 21:6850-6854 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | biology, 010405 organic chemistry, Stereochemistry, Chemistry, Alkaloid, Organic Chemistry, Analgesic, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Biochemistry, Skeleton (computer programming), Molecular conformation, Terpenoid, 0104 chemical sciences, Aconitum carmichaelii, Acetic acid, chemistry.chemical_compound, Structure–activity relationship, Physical and Theoretical Chemistry |
| الوصف: | Two sulfonated C20-diterpenoid alkaloid iminiums with a novel skeleton, named aconicatisulfonines A (1) and B (2), respectively, were isolated from a water extract of the Aconitum carmichaelii lateral roots. Structures of 1 and 2 were determined by spectroscopic data and quantum calculations as well as X-ray crystallographic analysis. Biosynthetic pathways via semipinacol rearrangements of atisane derivatives are proposed for 1 and 2. Compounds 1 and 2 exhibited remarkable analgesic activities against acetic acid-induced mice writhing. |
| تدمد: | 1523-7052 1523-7060 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::e64bac962ce3050fd460e20ca616f69cTest https://doi.org/10.1021/acs.orglett.9b02479Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........e64bac962ce3050fd460e20ca616f69c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
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