Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes
| العنوان: | Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes |
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| المؤلفون: | Michael Hummel, M Pflüger, Sandra Hummel, Anette-G. Ziegler, Ezio Bonifacio |
| المصدر: | Diabetes Care. 34:1301-1305 |
| بيانات النشر: | American Diabetes Association, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, medicine.disease_cause, law.invention, Autoimmunity, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Family history, Advanced and Specialized Nursing, chemistry.chemical_classification, Type 1 diabetes, geography, geography.geographical_feature_category, business.industry, Insulin, medicine.disease, Islet, Gluten, chemistry, Immunology, business |
| الوصف: | OBJECTIVE To determine whether delaying the introduction of gluten in infants with a genetic risk of islet autoimmunity is feasible, safe, and may reduce the risk of type 1 diabetes–associated islet autoimmunity. RESEARCH DESIGN AND METHODS A total of 150 infants with a first-degree family history of type 1 diabetes and a risk HLA genotype were randomly assigned to a first gluten exposure at age 6 months (control group) or 12 months (late-exposure group) and were followed 3 monthly until the age of 3 years and yearly thereafter for safety (for growth and autoantibodies to transglutaminase C [TGCAs]), islet autoantibodies to insulin, GAD, insulinoma-associated protein 2, and type 1 diabetes. RESULTS Adherence to the dietary-intervention protocol was reported from 70% of families. During the first 3 years, weight and height were similar in children in the control and late-exposure groups, as was the probability of developing TGCAs (14 vs. 4%; P = 0.1). Eleven children in the control group and 13 children in the late-exposure group developed islet autoantibodies (3-year risk: 12 vs. 13%; P = 0.6). Seven children developed diabetes, including four in the late-exposure group. No significant differences were observed when children were analyzed as per protocol on the basis of the reported first gluten exposure of the children. CONCLUSIONS Delaying gluten exposure until the age of 12 months is safe but does not substantially reduce the risk for islet autoimmunity in genetically at-risk children. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::d8c6845c630fb7af5b0ef4c91d8408daTest https://doi.org/10.2337/dc10-2456Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........d8c6845c630fb7af5b0ef4c91d8408da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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