We report the successful treatment of a 66-year-old man with failure of conventional local and general treatments for Kaposi sarcoma. He had a poor quality of life because of large ulcerated lesions on both legs. After the first electrochemotherapy session, the largest and the most painful lesions were cleared. Later on, repetitive electrochemotherapy sessions combined with the alternate use of imiquimod application led to an excellent local control with no secondary effect. This case demonstrates that electrochemotherapy can be safely and successfully repeated, with persistent excellent antitumour effects.
