Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia
| العنوان: | Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia |
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| المؤلفون: | Brooke M. Shafer, Anthony V. Incognito, André L. Teixeira, Jenna Benbaruj, Glen E. Foster, Tyler D. Vermeulen, Philip J. Millar, Massimo Nardone |
| المصدر: | Medicine & Science in Sports & Exercise. 53:2233-2244 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Mean arterial pressure, business.industry, Physical Therapy, Sports Therapy and Rehabilitation, Isometric exercise, Hypoxia (medical), medicine.disease, body regions, Obstructive sleep apnea, Internal medicine, Circulatory system, Heart rate, Occlusion, medicine, Reflex, Cardiology, Orthopedics and Sports Medicine, medicine.symptom, business |
| الوصف: | PURPOSE In normotensive patients with obstructive sleep apnea (OSA), the muscle sympathetic nerve activity (MSNA) response to exercise is increased while metaboreflex control of MSNA is decreased. We tested the hypotheses that acute intermittent hypercapnic hypoxia (IHH) in males free from OSA and associated comorbidities would augment the MSNA response to exercise but attenuate the change in MSNA during metaboreflex activation. METHODS Thirteen healthy males (age = 24 ± 4 yr) were exposed to 40 min of IHH. Before and after IHH, the pressor response to exercise was studied during 2 min of isometric handgrip exercise (at 30% maximal voluntary contraction), whereas the metaboreflex was studied during 4 min of postexercise circulatory occlusion (PECO). Mean arterial pressure (MAP), heart rate (HR), and fibular MSNA were recorded continuously. MSNA was quantified as burst frequency (BF) and total activity (TA). Mixed effects linear models were used to compare the exercise pressor and metaboreflex before and after IHH. RESULTS As expected, IHH led to significant increases in MSNA BF, TA, and MAP at baseline and throughout exercise and PECO. However, during handgrip exercise, the change from baseline in MAP, HR, MSNA BF, and TA was similar before and after IHH (All P > 0.31). During PECO, the change from baseline in MSNA BF and TA was similar after IHH, whereas the change from baseline in MAP (Δ14 mm Hg, 95% CI = 7-19, vs Δ16 mm Hg, 95% CI = 10-21; P < 0.01) was modestly increased. CONCLUSION After acute IHH, MSNA response to handgrip exercise and metaboreflex activation were preserved in healthy young males despite overall increases in resting MSNA and MAP. Chronic IHH and comorbidities often associated with OSA may be required to modulate the exercise pressor reflex and metaboreflex. |
| تدمد: | 1530-0315 0195-9131 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::d1f3fea6911ded92e9767c1557e7ac4aTest https://doi.org/10.1249/mss.0000000000002716Test |
| رقم الانضمام: | edsair.doi...........d1f3fea6911ded92e9767c1557e7ac4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300315 01959131 |
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