Blood Biomarkers for Healthy Aging
| العنوان: | Blood Biomarkers for Healthy Aging |
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| المؤلفون: | Ceereena Ubaida-Mohien, Toshiko Tanaka, Qu Tian, Zenobia Moore, Ruin Moaddel, Nathan Basisty, Eleanor M Simonsick, Luigi Ferrucci |
| المصدر: | Gerontology. |
| بيانات النشر: | S. Karger AG, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Aging, Geriatrics and Gerontology |
| الوصف: | Measuring the abundance of biological molecules and their chemical modifications in blood and tissues has been the cornerstone of research and medical diagnoses for decades. Although the number and variety of molecules that can be measured have expanded exponentially, the blood biomarkers routinely assessed in medical practice remain limited to a few dozen, which have not substantially changed over the last 30-40 years. The discovery of novel biomarkers would allow, for example, risk stratification or monitoring of disease progression or the effectiveness of treatments and interventions, improving clinical practice in myriad ways. In this review, we combine the biomarker discovery concept with geroscience. Geroscience bridges aging research and translation to clinical applications by combining the framework of medical gerontology with high-technology medical research. With the development of geroscience and the rise of blood biomarkers, there has been a paradigm shift from disease prevention and cure to promoting health and healthy aging. New -omic technologies have played a role in the development of blood biomarkers, including epigenetic, proteomic, metabolomic, and lipidomic markers, which have emerged as correlates or predictors of health status, from disease and exceptional health. |
| تدمد: | 1423-0003 0304-324X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ae36434a4f6aa82980b23a48ead23872Test https://doi.org/10.1159/000530795Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........ae36434a4f6aa82980b23a48ead23872 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230003 0304324X |
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