929-P: A Population-Based Study of Long-Term HbA1c Associated with Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Western Australian Children
| العنوان: | 929-P: A Population-Based Study of Long-Term HbA1c Associated with Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Western Australian Children |
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| المؤلفون: | Timothy W. Jones, Elizabeth A. Davis, Helen Clapin, Aveni Haynes, Sathyakala Vijayanand, Grant J. Smith |
| المصدر: | Diabetes. 70 |
| بيانات النشر: | American Diabetes Association, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, education.field_of_study, Type 1 diabetes, endocrine system diseases, Diabetic ketoacidosis, business.industry, Endocrinology, Diabetes and Metabolism, Incidence (epidemiology), Population, nutritional and metabolic diseases, medicine.disease, Population based study, Increasing risk, Economic viability, Cohort, Internal Medicine, Medicine, business, education |
| الوصف: | Background: In addition to the acute illness associated with DKA at diagnosis of T1D in children, there is some evidence of its association with poor long-term glycaemic outcomes, increasing risk of complications. With growing global interest in screening for pre-diabetes in children, long-term outcomes are an important consideration in terms of economic viability but there is limited high quality data. This population-based study helps to address this gap. Methods: All children Results: The population-based cohort included 2063 patients and median [IQR] follow-up time was 5.4 [3.0-8.4] years. The incidence of DKA at diagnosis was 25%. Patients presenting with DKA had a higher mean HbA1c at diagnosis as expected but from 2 to 7 years post-diagnosis there was no difference between the two groups. Mean HbA1c of patients presenting with DKA increased relative to the remainder from 7 years. The only comparable study, conducted in Colorado in 2017, reported an immediate and sustained relationship between DKA severity at onset and HbA1c over 15 years. Conclusion: The difference in findings for similar cohorts in Australia and the US raises questions regarding the variables that influence long-term glycaemic outcomes in children diagnosed with T1D. Further studies are required to explore the association between DKA at diagnosis and HbA1c over time and to understand the importance of sociodemographic, physiological and other factors. Disclosure H. Clapin: None. G. J. Smith: None. S. Vijayanand: None. T. Jones: None. E. A. Davis: None. A. Haynes: None. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ab356c77aa53761d2dd9a06ef548d37aTest https://doi.org/10.2337/db21-929-pTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........ab356c77aa53761d2dd9a06ef548d37a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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