Cul3 is required for normal development of the mammary gland
| العنوان: | Cul3 is required for normal development of the mammary gland |
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| المؤلفون: | Cristina M. Cummings, Jeffrey D. Singer |
| المصدر: | Cell and Tissue Research. 385:49-63 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Histology, Autophagy, Mammary gland, Cell Biology, Biology, medicine.disease_cause, Molecular medicine, Pathology and Forensic Medicine, Mammary gland development, Andrology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, medicine, Involution (medicine), Carcinogenesis, 030217 neurology & neurosurgery, Mammary Fat Pad, Oxidative stress |
| الوصف: | Cullin 3 (Cul3) has recently been implicated in a multitude of different processes, including the oxidative stress response, autophagy, tumorigenesis, and differentiation. To investigate the role of Cul3 in mammary gland development, we created a mouse model system using Cre-lox targeting where Cul3 is specifically deleted from the mammary gland. Such MMTV-Cre Cul3Flx/Flx mice examined at 2 and 3 months of age show delays and defects in mammary gland development. Mammary ductal trees from Cul3-deficient mammary glands exhibit delayed forward growth through the mammary fat pad, dilation of the ducts, and abnormal morphology of some of the epithelial structures within the gland. Additionally, terminal end buds are larger and less plentiful in MMTV-Cre Cul3Flx/Flx mammary glands, and there is significantly less primary and secondary branching compared to control animals. In contrast, by 6 months of age, the mammary ductal tree has grown to fill the entire mammary fat pad in glands lacking Cul3. However, distorted epithelial structures and dilated ducts persist. MMTV-Cre Cul3Flx/Flx mothers are able to nourish their litters, but the process of involution is slightly delayed in mammary glands lacking Cul3. Therefore, we conclude that while Cul3 is not essential for mammary gland function, Cul3 is required for the mammary gland to proceed normally through development. |
| تدمد: | 1432-0878 0302-766X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a630eb47374ec68ab9ef0db0f4143fecTest https://doi.org/10.1007/s00441-021-03456-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........a630eb47374ec68ab9ef0db0f4143fec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320878 0302766X |
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