Resolution of type I Chiari malformation and associated syringomyelia following intrathecal chemotherapy: case report
| العنوان: | Resolution of type I Chiari malformation and associated syringomyelia following intrathecal chemotherapy: case report |
|---|---|
| المؤلفون: | Jung-Shun Lee, Yi Shan Tsai, Yu Ning Chen, Chia En Wong, Jiann Shiuh Chen |
| المصدر: | Journal of Neurosurgery: Pediatrics. 27:145-150 |
| بيانات النشر: | Journal of Neurosurgery Publishing Group (JNSPG), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Chemotherapy, Foramen magnum, medicine.medical_specialty, business.industry, medicine.medical_treatment, Induction chemotherapy, General Medicine, medicine.disease, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cytology, Medicine, Radiology, business, 030217 neurology & neurosurgery, Type I Chiari malformation, Syringomyelia |
| الوصف: | Type I Chiari malformation (CM-I) consists of downward herniation of the cerebellar tonsils below the foramen magnum and often requires surgical decompression if symptomatic. Spontaneous resolution of CM-I is rare. We present a case of resolved CM-I without surgery in a 6-year-old boy with B-cell lymphoma who was diagnosed with CM-I during lymphoma staging. Cerebrospinal fluid cytology and brain MRI revealed negative CNS involvement but showed CM-I with tonsillar ectopia 19 mm below the foramen magnum. The patient underwent induction chemotherapy including 5 doses of intrathecal chemotherapy. Follow-up MRI demonstrated marked regression of CM-I to less than 6 mm in 3 months, and complete resolution of CM-I was observed in 2 years. To the best of our knowledge, this is the first case of resolved CM-I and syringomyelia following chemotherapy. In this case report, the authors summarize all of the clinical characteristics, the radiological appearance, and the potential causes of resolution based on a review of the literature and propose the mechanisms through which intrathecal chemotherapy contributed to the CM-I and syringomyelia resolution in the present case. |
| تدمد: | 1933-0715 1933-0707 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9f297e1ed0004b7349469d252b40e5abTest https://doi.org/10.3171/2020.7.peds20411Test |
| رقم الانضمام: | edsair.doi...........9f297e1ed0004b7349469d252b40e5ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19330715 19330707 |
|---|