Post hoc longitudinal assessment of efficacy and safety of recombinant factor IX Fc fusion protein in hemophilia B
| العنوان: | Post hoc longitudinal assessment of efficacy and safety of recombinant factor IX Fc fusion protein in hemophilia B |
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| المؤلفون: | Amy D. Shapiro, Roshni Daniel Kulkarni, Margaret V Ragni, Herve Chambost, Johnny N Mahlangu, Johannes Oldenburg, Beatrice Nolan, Margareth C Ozelo, Meredith C Foster, Annemieke Willemze, Chris Barnowski, Nisha Jain, Bent Winding, Jennifer Dumont, Stefan Lethagen, Chris Barnes, K John Pasi |
| المصدر: | Blood Advances. |
| بيانات النشر: | American Society of Hematology, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Hematology |
| الوصف: | Long-term efficacy and safety of the extended half-life recombinant FIX Fc fusion protein (rFIXFc) has been established in previously treated patients with severe hemophilia B in 2 Phase 3 trials (B-LONG [NCT01027364] and Kids B-LONG [NCT01440946]) and a long-term extension study (B-YOND [NCT01425723]). Here we report post hoc analyses of pooled longitudinal data up to 6.5 years for rFIXFc prophylaxis. In B-LONG, subjects ≥12 years received weekly dose-adjusted prophylaxis (WP; starting dose 50 IU/kg), individualized interval-adjusted prophylaxis (IP; 100 IU/kg every 10 days initially), or on-demand dosing. In Kids B-LONG, subjects |
| تدمد: | 2473-9537 2473-9529 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9b3492f3b3a5f76dd4bbf7bdc817f3ebTest https://doi.org/10.1182/bloodadvances.2022009230Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........9b3492f3b3a5f76dd4bbf7bdc817f3eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24739537 24739529 |
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