On‐Site Laser Photobiomodulation Treatment of Crushed Muscle Due to Prolonged Pressure in Rats
العنوان: | On‐Site Laser Photobiomodulation Treatment of Crushed Muscle Due to Prolonged Pressure in Rats |
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المؤلفون: | Shimon Rochkind, Moshe Nissan, Igal Koifman, Yoram Wollman, Mara Almog |
المصدر: | Lasers in Surgery and Medicine. 53:1258-1265 |
بيانات النشر: | Wiley, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | business.industry, Dermatology, Hindlimb, Muscle injury, medicine.disease, Functional recovery, Laser, 01 natural sciences, law.invention, 010309 optics, 030207 dermatology & venereal diseases, 03 medical and health sciences, Electrophysiology, Gastrocnemius muscle, 0302 clinical medicine, law, Anesthesia, Left hindlimb, 0103 physical sciences, Crush injury, medicine, Surgery, business |
الوصف: | Background and objectives Crush injuries and prolonged pressure on muscles lead to bruises and sprains and, in most of the cases, cause distraction of the muscle and release of particles into the blood stream, causing renal and systemic complications in severe cases. Laser photobiomodulation treatment (i.e., laser phototherapy) is a method suggested to decrease the pressure damage in the first 24-48 hours after muscle injury, allowing a faster and more complete physical rehabilitation. We studied the efficacy of non-invasive laser photobiomodulation treatment as an on-site treatment for crush-injured gastrocnemius muscles, developing a moderate muscle crush injury model and aiming at decreasing damage extent while regaining physical competence faster. Study design/materials and methods Muscle crush injury was performed on 30 female Wistar rats using direct pressure for 10 minutes on the gastrocnemius muscle in both left and right hindlimbs. Immediately after the injury, only the left hindlimb were irradiated for 16 minutes (with 780 nm laser with a power of 250 mW, the energy at the target was 240 J, and the fluence was 1019 J/cm2 ) for 1, 3, or 7 consecutive days, and sacrificed accordingly. During the follow-up period, 1, 3, or 7 days, both gastrocnemius muscles (of the treated and untreated hindlimbs) were evaluated for electrophysiology and functionality. Results The laser photobiomodulation treatment showed a significant electrophysiological and functional recovery of the gastrocnemius muscle during the first 3 days after injury, in comparison with the untreated hindlimb. Conclusions These preliminary results are promising, showing a significant effect of the laser photobiomodulation treatment during the first 3 days after the induction of the muscle crush injury, which is the most critical period in the clinical aspect. These findings suggest a therapeutic approach, which may help restore the muscle after crush injury. |
تدمد: | 1096-9101 0196-8092 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::996cee7e6fd4c7c38a8f889603c173c5Test https://doi.org/10.1002/lsm.23417Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi...........996cee7e6fd4c7c38a8f889603c173c5 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 10969101 01968092 |
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