Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome
| العنوان: | Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome |
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| المؤلفون: | Tomoyuki Endo, Koichi Miyamura, Yachiyo Kuwatsuka, Masashi Sawa, Makoto Onizuka, Yoshiko Atsuta, Noriko Fukuhara, Hiroatsu Iida, Kotaro Miyao, Akio Kohno, Atsumi Yanagisawa, Shingo Kurahashi, Hisayuki Yokoyama, Tatsunori Goto, Seitaro Terakura, Masanobu Kasai, Mika Nakamae, Makoto Murata, Nobuhiro Kanemura, Yasuo Tomiya, Nobuharu Fujii, Hiroatsu Ago, Yasushi Onishi, Tomonori Kato, Tetsuya Nishida, Yuichiro Nawa, Yasuyuki Nagata, Ritsuro Suzuki, Satoshi Iyama, Nagoya Blood, Yukiyasu Ozawa, Kazutaka Ozeki |
| المصدر: | Bone Marrow Transplantation. 55:1399-1409 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Transplantation, medicine.medical_specialty, Acute leukemia, Multivariate analysis, business.industry, medicine.medical_treatment, Phases of clinical research, Hematology, Hematopoietic stem cell transplantation, Internal medicine, Cord blood, Medicine, Stem cell, business, Prospective cohort study |
| الوصف: | A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors (UD) and cord blood (CB) on outcomes in adult acute leukemia (AL) and myelodysplastic syndrome (MDS). Between 2007 and 2015, 231 transplant-eligible patients were registered for a phase 2 study of alternative donor transplantation. After registration, a sufficient time period was given to find appropriate UD. Patients received CB transplantation (CBT) if an appropriate UD was unavailable. In total, 119 patients received CBT (106 AL and 13 MDS) and 91 patients received UD transplantation (UDT) (86 AL and 5 MDS). The median age was 39 years in both groups. The primary objective was overall survival (OS); secondary objectives included cumulative incidences of non-relapse mortality (NRM) and relapse, and disease-free survival. Diagnosis, disease status at transplantation, refined disease risk index, and hematopoietic cell transplant-specific comorbidity index did not differ between UDT and CBT. In multivariate analyses, graft source was not a significant risk factor for all objectives. In adjusted analyses, UDT and CBT showed similar OS, NRM, and relapse in this prospective study. CB can be a comparable alternative stem cell source to UD by achieving a timely transplant. |
| تدمد: | 1476-5365 0268-3369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::974b0c0201f4facfa76e1570673e7faaTest https://doi.org/10.1038/s41409-020-0859-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........974b0c0201f4facfa76e1570673e7faa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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