Spectrophotometric procedures for the determination of roxithromycin in pharmaceutical formulations
| العنوان: | Spectrophotometric procedures for the determination of roxithromycin in pharmaceutical formulations |
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| المؤلفون: | Davuluri S. Prasad, Chilukuri S. P. Sastry, Kolli Rama Rao |
| المصدر: | Mikrochimica Acta. 122:53-60 |
| بيانات النشر: | Springer Science and Business Media LLC, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Chloroform, Chromatography, medicine.diagnostic_test, Roxithromycin, Vanillin, Color reaction, Hydrochloric acid, Dosage form, Analytical Chemistry, chemistry.chemical_compound, chemistry, Spectrophotometry, medicine, Acid dye, medicine.drug |
| الوصف: | Four simple and sensitive visible spectrophotometric procedures for the assay of roxithromycin (RXT) have been developed. Procedures A and B are based on the formation of ion-pairs of roxithromycin with the dyes supracen violet 3B and tropaeolin 000, which are extracted into chloroform and have absorption maxima at 590 nm (SV 3B) and 490 nm (TP 000). Procedures C and D are based on condensation between the hydrolysis product of RXT in the presence of 3.6M hydrochloric acid in acetic acid medium and vanillin orp-dimethylaminobenzaldehyde (PDAB) to form coloured products with λmax at 500 nm. Regression analysis of the Beer's plot showed good correlation in the concentration ranges 5–60 (A), 5–40 (B) and 5–50 (C & D) μg/ml. No interference was observed from excipients and the validity of the procedures was tested by analysing pharmaceutical formulations. Recoveries were 99.0–102.0%. The concentration measurements are reproducible within a relative standard deviation of 1.0%. |
| تدمد: | 1436-5073 0026-3672 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::8d3d9e4b5dbffd49f15a85c602210df7Test https://doi.org/10.1007/bf01252405Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........8d3d9e4b5dbffd49f15a85c602210df7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14365073 00263672 |
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