Mycophenolate mofetil: a step forward in the induction treatment of ANCA-associated vasculitis? Comment on the article by Joneset al
| العنوان: | Mycophenolate mofetil: a step forward in the induction treatment of ANCA-associated vasculitis? Comment on the article by Joneset al |
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| المؤلفون: | Christophe Lelubre, Frédéric Alain Vandergheynst |
| المصدر: | Annals of the Rheumatic Diseases. 79:e100-e100 |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 030203 arthritis & rheumatology, 0301 basic medicine, medicine.medical_specialty, business.industry, Immunology, Absolute risk reduction, ANCA-Associated Vasculitis, medicine.disease, Mycophenolate, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Intravenous cyclophosphamide, Rheumatology, Internal medicine, medicine, Immunology and Allergy, Granulomatosis with polyangiitis, business, INDUCTION TREATMENT |
| الوصف: | We have read with interest the results of the MYCYC trial showing that mycophenolate mofetil (MMF) is not inferior to intravenous cyclophosphamide (CYC) in achieving a primary remission in the treatment of ANCA-associated vasculitides (AAV).1 We would like to address several comments. First, in a previous report of the MYCYC trial in 2013, the authors could not establish a non-inferiority of MMF compared with CYC because the lower bound of the 90% CI of the absolute risk difference (RD) crossed the prespecified non-inferiority margin of −12% (MMF: n=46/70 (66%) vs CYC: n=48/70 (69%), RD=−3%, 90% CI −16% to 10%, p=0.06).2 In the current publication, the reported primary remission rates at 6 months are slightly different compared … |
| تدمد: | 1468-2060 0003-4967 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::8c855de9b422577fc744179d04bc05a4Test https://doi.org/10.1136/annrheumdis-2019-215647Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........8c855de9b422577fc744179d04bc05a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682060 00034967 |
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