TACE plus sorafenib for the treatment of hepatocellular carcinoma: Final results of the multicenter SOCRATES trial
| العنوان: | TACE plus sorafenib for the treatment of hepatocellular carcinoma: Final results of the multicenter SOCRATES trial |
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| المؤلفون: | A. Erhardt, Henning Wege, M. Schuchmann, C. Gog, Michael Bitzer, E. Schott, Frank T. Kolligs, Christian Ohmann, Matthias M. Dollinger, C. Walter, J. Raedle, D. Haeussinger, D. Blondin |
| المصدر: | Journal of Clinical Oncology. 29:4107-4107 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Sorafenib, Cancer Research, medicine.medical_specialty, business.industry, Child–Pugh score, Phases of clinical research, Milan criteria, medicine.disease, Gastroenterology, digestive system diseases, Oncology, Internal medicine, Hepatocellular carcinoma, Lipiodol, Clinical endpoint, Medicine, Doxorubicin, business, Nuclear medicine, neoplasms, medicine.drug |
| الوصف: | 4107 Background: HCC is considered to be a hypervascular tumor. Therefore, transarterial chemoembolization (TACE) and inhibition of angiogenesis appear rational treatment strategies. The present multicenter phase II study investigated for the first time the combination of TACE and sorafenib, a multikinase inhibitor with anti-angiogenic activities approved for the treatment of HCC. Methods: Eligibility criteria included histologically confirmed, unresectable hepatocellular carcinoma beyond Milan criteria, no extrahepatic spread, Child Pugh score ≤8, ECOG PS 0-2, platelets >100K/µl, and bilirubin |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::89dfb1c5c4789562289c9cc5310a8ca2Test https://doi.org/10.1200/jco.2011.29.15_suppl.4107Test |
| رقم الانضمام: | edsair.doi...........89dfb1c5c4789562289c9cc5310a8ca2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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