Prescribed daily doses and ‘risk factors’ associated with the use of benzodiazepines in primary care
| العنوان: | Prescribed daily doses and ‘risk factors’ associated with the use of benzodiazepines in primary care |
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| المؤلفون: | C. De las Cuevas, J.A. De la Fuente, Casimiro Cabrera, Alfonso Fernández Mateos, Emilio J. Sanz |
| المصدر: | Pharmacoepidemiology and Drug Safety. 8:207-216 |
| بيانات النشر: | Wiley, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Clinical audit, medicine.medical_specialty, Benzodiazepine, education.field_of_study, Epidemiology, medicine.drug_class, business.industry, Population, Pharmacoepidemiology, Logistic regression, Stratified sampling, Hypnotic, Family medicine, medicine, Pharmacology (medical), Medical prescription, education, Psychiatry, business |
| الوصف: | Objective To assess the extent, characteristics and determinants of benzodiazepine prescription in outpatient Primary Health Care. Methods A clinical audit of a stratified random sample of Primary Health Care Centres in the seven islands and 1.6 million inhabitants region of ‘Canarias’ in Spain was carried out. From those centres, a random sample of 1045 clinical records was reviewed and information on diagnosis, prescription and prescribed dosages was collected in a structured questionnaire. A multivariate logistic regression analysis was performed in order to determine the ‘risk factors’ for the use of benzodiazepines. Results Benzodiazepine prescription was recorded in 23.4% of all clinical records; 87.7% of these were for benzodiazepines classified as anxiolytics (N05B) and 12.3% for hypnotics (N05C2). Benzodiazepine prescription was more common for women, elderly, widowed, divorced, low educational background, housewives and retired people. Using multivariate logistic regression, the probability of benzodiazepine prescription was found to be closely related to age, gender and employment status, but not with educational level. Prescribed Daily Doses were lower than Defined Daily Doses (DDD) in 77.1% of all anxiolytic prescriptions, but were in agreement with DDD in 90% of hypnotic prescriptions. The duration of treatment recorded in the clinical records was 25±21 months, with a range of 1 and 144 months. General Practitioners were responsible for 67% of all benzodiazepine prescription. Anxiolytics were prescribed as a single daily dose in 57% of the cases, and only ‘at supper’ in 48.6%. Conclusion In the general population attending Primary Health Care Centres of the Canary Islands Health System the prescription of benzodiazepines is higher for women and the elderly, and the most common use is chronic, with a duration of over 2 years in most cases. Anxiolytics are prescribed in doses which are much lower than those used as DDD and were used only ‘at night’ in almost half of the cases. This could represent an overlapping of the indications with hypnotics, and explain part of the huge difference in the use of anxiolytics in Spain compared with other figures in Europe. This fact must also be taken into account when making inferences of benzodiazepine use from sales statistics, which are very imprecise measures of drug use. Copyright © 1999 John Wiley & Sons, Ltd. |
| تدمد: | 1099-1557 1053-8569 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::85ca7f33f36af51373b1e832e6cf567eTest https://doi.org/10.1002Test/(sici)1099-1557(199905/06)8:3<207::aid-pds421>3.0.co;2-1 |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........85ca7f33f36af51373b1e832e6cf567e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991557 10538569 |
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