Anticancer activity of novel Schiff bases and azo dyes derived from 3-amino-4-hydroxy-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione
| العنوان: | Anticancer activity of novel Schiff bases and azo dyes derived from 3-amino-4-hydroxy-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione |
|---|---|
| المؤلفون: | Abdeltawab M. Saeed, Shaikha S. AlNeyadi, Ibrahim M. Abdou |
| المصدر: | Heterocyclic Communications. 26:192-205 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, 010405 organic chemistry, Pyran, Organic Chemistry, Quinoline, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences |
| الوصف: | New Schiff bases and azo dyes derivatives have been synthesized via appropriate conventional methods using pyranoquinolinone as a starting material. The compounds obtained were characterized by spectral analysis and evaluated for anticancer activity in several human tumor cell lines: MCF-7 breast cancer, HepG2 liver cancer and HCT-116 colon carcinoma. 5-fluorouracil was used as a reference drug. The in vitro cytotoxicity screening results revealed that all tested compounds showed promising activity against MCF-7 cells. In particular, compounds 6a, 6b, and 7b showed excellent activity against the three human tumor cell lines. Structure-activity relationship studies indicated that the azo derivative with a trifluoromethoxy group (compound 7b) was the most potent candidate against the three human tumor cell lines (IC50, 1.82-8.06 μg/mL). Our findings highlight pyranoquinolinone analogues as a promising class of compounds for new anticancer therapies. |
| تدمد: | 2191-0197 0793-0283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::843df3258b98dd73401a7d15af676f5dTest https://doi.org/10.1515/hc-2020-0116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........843df3258b98dd73401a7d15af676f5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910197 07930283 |
|---|