Herausforderung Diabetestherapie: Effekte der Glitazone jenseits der Blutzuckerkontrolle
| العنوان: | Herausforderung Diabetestherapie: Effekte der Glitazone jenseits der Blutzuckerkontrolle |
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| المؤلفون: | Oliver Schnell, Markolf Hanefeld, Guntram Schernthaner, C Rosak, Erland Erdmann, Thomas Forst, Jochen Seufert, D. Tschöpe, G Linss, W Haberbosch, D Gulba, W März, H Mehnert |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 134:949-954 |
| بيانات النشر: | Georg Thieme Verlag KG, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Insulin, medicine.medical_treatment, General Medicine, Type 2 diabetes, medicine.disease, Diabetes Therapy, Blood pressure, Endocrinology, Insulin resistance, Diabetes mellitus, Internal medicine, medicine, Cardiology, business, Rosiglitazone, Pioglitazone, medicine.drug |
| الوصف: | Not just since the results of ACCORD, ADVANCE and VADT were published, it is clear that lowering blood glucose alone does not reduce the cardiovascular risk of patients with type 2 diabetes. In fact, many studies also indicate that some treatment strategies may even have adverse effects. To treat type 2 diabetes appropriately, the co-morbidities such as diabetic dyslipidaemia, hypertension or nephropathy must also be taken into account. Thiazolidinediones reduce insulin resistance thus allowing to direct the treatment of type 2 diabetes towards its pathophysiologic origin. Due to their mechanism of action, thiazolidinediones not only lower blood glucose but have also beneficial effects on inflammatory and atherogenic parameters, blood pressure and microalbuminuria. Furthermore pioglitazone improves dyslipidaemia and reduces mortality, myocardial infarction and stroke in high risk patients. Effects of rosiglitazone on the cardiovascular risk are yet unclear. Numerous studies document the efficacy and safety of thiazolidinediones and provide a basis for an evidence-based therapeutic approach beyond blood glucose control. |
| تدمد: | 1439-4413 0012-0472 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::773601cebc7bbb2134c12b1c58d5977cTest https://doi.org/10.1055/s-0029-1220255Test |
| رقم الانضمام: | edsair.doi...........773601cebc7bbb2134c12b1c58d5977c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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