Pristine and modified-mesoporous alumina: molecular assistance-based drug loading and sustained release activity
| العنوان: | Pristine and modified-mesoporous alumina: molecular assistance-based drug loading and sustained release activity |
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| المؤلفون: | Kamalika Sen, Pritam Singh, P.K. Maiti |
| المصدر: | Bulletin of Materials Science. 43 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, chemistry.chemical_classification, Materials science, Cyclodextrin, Hip joint prosthesis, media_common.quotation_subject, Intermolecular force, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Amino acid, chemistry, Mechanics of Materials, General Materials Science, 0210 nano-technology, Mesoporous material, media_common |
| الوصف: | The present article reports on the synthesis of mesoporous alumina and its modification through $$\upbeta $$ -cyclodextrin (BCD) incorporation for loading and release studies of amoxicillin. The drug loading in the mesoporous matrices was found to be activated upon providing molecular assistance by amino acids, L-methionine, L-proline and L-phenylalanine. The effect of molecular assistance has been attributed to intermolecular interactions between the drug and the individual amino acids which have been further confirmed by different spectroscopic studies. The drug-loaded material with BCD modification was found to exhibit a sustained release mechanism in physiological pH and is suggested as a proposed material for hip joint prosthesis. |
| تدمد: | 0973-7669 0250-4707 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::718c97c27e2a92098b9f8c0fdf28b224Test https://doi.org/10.1007/s12034-019-1991-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........718c97c27e2a92098b9f8c0fdf28b224 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09737669 02504707 |
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