Effects of dietary methionine restriction on postnatal growth, insulin sensitivity, and glucose metabolism in intrauterine growth retardation pigs at 49 and 105 d of age1
| العنوان: | Effects of dietary methionine restriction on postnatal growth, insulin sensitivity, and glucose metabolism in intrauterine growth retardation pigs at 49 and 105 d of age1 |
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| المؤلفون: | Yue Li, Le Zhou, Weipeng Su, Xiaoke Ge, Lili Zhang, Zhixiong Ying, Hao Zhang, Tian Wang |
| المصدر: | Journal of Animal Science. 97:610-619 |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, medicine.medical_treatment, Blood sugar, Carbohydrate metabolism, Biology, 03 medical and health sciences, chemistry.chemical_compound, Insulin resistance, Internal medicine, Genetics, medicine, Weaning, reproductive and urinary physiology, 030304 developmental biology, 0303 health sciences, Methionine, Glycogen, Insulin, 0402 animal and dairy science, 04 agricultural and veterinary sciences, General Medicine, medicine.disease, 040201 dairy & animal science, female genital diseases and pregnancy complications, Endocrinology, Blood chemistry, chemistry, Animal Science and Zoology, Food Science |
| الوصف: | This study was conducted to investigate the effects of methionine restriction (MR) on growth performance, insulin sensitivity, and hepatic and muscle glucose metabolism in intrauterine growth retardation (IUGR) pigs at 49 and 105 d of age. At weaning (day 21), 30 female normal birth weight (NBW) piglets were fed control diets with adequate methionine (NBW-CON), whereas 60 female IUGR piglets were fed either the control diets (IUGR-CON) or MR diets which were 30% reduced in methionine (IUGR-MR) (n = 6 replicates (pens) with five piglets per replicate). At 49 and 105 d of age, one pig with a BW near to the mean of each replication was selected for biochemical analysis. Compared with NBW-CON pigs, IUGR-CON pigs exhibited lower relative daily gain (RDG) and homeostasis model assessment of insulin resistance (HOMA-IR) index at day 49 (P 0.05). Compared with IUGR-CON pigs, IUGR-MR pigs had lower RDG at day 49, less blood glucose at day 105, and lower HOMA-IR index at both days 49 and 105 (P < 0.05). Additionally, compared with IUGR-CON pigs, MR decreased IUGR-MR pigs' hepatic G6Pase activities and increased their hepatic glycogen contents at day 105 (P < 0.05), as well as increased their hepatic and muscle PKB/Akt phosphorylation (P < 0.05). In conclusion, the ability of dietary MR to restrict IUGR pigs' growth and to reduce blood glucose appeared, respectively, in earlier and later period, but MR improved IUGR pigs' insulin sensitivity at both days 49 and 105. |
| تدمد: | 1525-3163 0021-8812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::6f3e1f1c63fd3279e7593e67b69e7795Test https://doi.org/10.1093/jas/sky457Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........6f3e1f1c63fd3279e7593e67b69e7795 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15253163 00218812 |
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