TM1-5 Optimising observation strategies for incidentally discovered intracranial meningiomas
| العنوان: | TM1-5 Optimising observation strategies for incidentally discovered intracranial meningiomas |
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| المؤلفون: | Brian Haylock, Rdc Moon, Nitika Rathi, Ruwanthi Kolamunnage-Dona, Jenkinson, Abdurrahman I. Islim, Midhun Mohan, Andrew Brodbelt, Samantha J Mills |
| المصدر: | Journal of Neurology, Neurosurgery & Psychiatry. 90:e9.3-e10 |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Treatment options, Retrospective cohort study, Model parameters, Mean age, medicine.disease, Comorbidity, Psychiatry and Mental health, Tumour size, Prognostic model, Medicine, Surgery, Neurology (clinical), Radiology, business, Median time to failure |
| الوصف: | ObjectivesDevelop a model to identify incidental meningiomas at risk of observation failure.DesignRetrospective study (2007–2015).Subjects385 patients. Mean age 62.6 years.MethodsObservation failure was defined as: new symptoms, MRI progression (absolute growth rate 2 cm3/year or absolute growth rate 1 cm3/year +relative growth rate 30%/year) or loss of treatment options. A prognostic model was developed using MRI and patient comorbidity.ResultsOver a median of 36 months, 44 (10.9%) meningiomas failed observation. Median time to failure was 33 months. Model parameters were based on statistical and clinical considerations and included: increasing tumour size (HR=2.17 [95% CI=1.53–3.09], pConclusionsMost meningiomas remain clinically and radiologically stable. Stratifying follow-up according to risk-group has the potential to reduce the cost to healthcare. |
| تدمد: | 1468-330X 0022-3050 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::6b7a49c2face86c5a48a887260bbfcd5Test https://doi.org/10.1136/jnnp-2019-abn.29Test |
| رقم الانضمام: | edsair.doi...........6b7a49c2face86c5a48a887260bbfcd5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468330X 00223050 |
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