Immunology in influenza infection: A systematic review on the roles of autophagy, CD200 receptor, reactive oxygen species and secretory leukocyte protease inhibitor
التفاصيل البيبلوغرافية
العنوان:
Immunology in influenza infection: A systematic review on the roles of autophagy, CD200 receptor, reactive oxygen species and secretory leukocyte protease inhibitor
Influenza A infection is accompanied by an effervescent immune response associated with a cytokine storm triggered towards annihilating the viral intrusion in the body. This aggressive reaction is accompanied with an intense cytopathology, ultimately proving fatal to the host. Recent researches gaining insight into the roles of autophagy, CD200 Receptor (CD200R), reactive oxygen species (ROS) and secretory leukocyte protease inhibitor (SLPI) are suggestive of specialized roles exhibited by these biological molecules in influenza infection. Decreased autophagy serves to reduce the proliferation of the virus, thereby diminishing the viral titers. CD200R when activated, decrease the rate and extent of immunostimulation and hence abating the immunopathology under pathogenicity of influenza infection. Production of high levels of ROS owing to high activity of alveolar macrophages typically leads to an amplified lymphocytic infiltration exacerbating the pathology. Anti-proteases like SLPI indirectly decrease the entry of influenza virus into the target cells. Drugs or biologicals modulating all these immune components would defeat the strategy of consistent antigenic shifts and drifts exhibited by these viruses and promise to categorize themselves as potential non-conventional therapeutic agents not affected by the variations occurring in the glycoproteins over the viral envelopes.
