Antagonism of P2Y12reduces physiological thromboxane levels
| العنوان: | Antagonism of P2Y12reduces physiological thromboxane levels |
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| المؤلفون: | Alan T. Nurden, Theodore Kent Gartner, Jianguo Jin, Alexander Georgakis, Yoshiaki Tomiyama, Paquita Nurden, Kamala Bhavaraju, Satya P. Kunapuli |
| المصدر: | Platelets. 21:604-609 |
| بيانات النشر: | Informa UK Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | medicine.medical_specialty, Aspirin, Prasugrel, biology, Thromboxane, business.industry, Hematology, General Medicine, Pharmacology, Clopidogrel, Endocrinology, P2Y12, Internal medicine, medicine, biology.protein, Platelet, Thromboxane-A synthase, business, Ex vivo, medicine.drug |
| الوصف: | Antiplatelet therapy for the management of patients with cardiovascular risks often includes a combination therapy of aspirin and clopidogrel, acting through inhibition of thromboxane generation and blockade of Gi-coupled P2Y12 receptor, respectively. We hypothesized that ADP acting through P2Y12 regulates physiological thromboxane levels. The serum thromboxane levels in mice (n = 3) dosed with clopidogrel and prasugrel were decreased by 83.1 ± 5.3% and 94.26 ± 1.75% respectively compared to untreated mice. Pre-treatment of human blood (n = 3) ex vivo with active metabolites of clopidogrel or prasugrel led to a reduction in thromboxane levels to 16.3 ± 3.2% and 4.9 ± 0.8% respectively, compared to untreated human serum. We also evaluated serum thromboxane levels in P2Y receptor null mice (n = 4). Whereas serum thromboxane levels in P2Y1 null mice were similar to those in wild type littermates, those in the P2Y12 null mice were inhibited by 83.15 ± 3.8%. Finally, in a pilot study, serum thromboxane levels ... |
| تدمد: | 1369-1635 0953-7104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::5c518389d9919ee7a6ac5ffb2a3a23a2Test https://doi.org/10.3109/09537104.2010.511684Test |
| رقم الانضمام: | edsair.doi...........5c518389d9919ee7a6ac5ffb2a3a23a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13691635 09537104 |
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