Hypoglycemic and Hypolipidemic Activity of Polygonatum sibiricum Fermented with Lactobacillus brevis YM 1301 in Diabetic C57BL/6 Mice
| العنوان: | Hypoglycemic and Hypolipidemic Activity of Polygonatum sibiricum Fermented with Lactobacillus brevis YM 1301 in Diabetic C57BL/6 Mice |
|---|---|
| المؤلفون: | Yaxian Shang, Yao Wang, Jixia Li, Nan Xue, Chunying Huang, Gao Jingru, Li Farong, Jia Li, Caiyun Li |
| المصدر: | Journal of Medicinal Food. 24:720-731 |
| بيانات النشر: | Mary Ann Liebert Inc, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Nutrition and Dietetics, Triglyceride, Chemistry, Insulin, medicine.medical_treatment, Medicine (miscellaneous), Adipose tissue, White adipose tissue, Pharmacology, medicine.disease, chemistry.chemical_compound, Insulin resistance, Carnitine palmitoyltransferase 1, Lipogenesis, medicine, Lipolysis |
| الوصف: | Polygonatum sibiricum (PS) has been used as herbal medicine to treat type 2 diabetes mellitus (T2DM). However, how lactic acid fermentation of PS influences glucose and lipid metabolism remains unclear. The current study was undertaken to evaluate the hypoglycemic and hypolipidemic effects of PS fermented with Lactobacillus brevis YM 1301 (YM 1301) in streptozotocin and high-fat diet-induced T2DM mice. Biochemical analysis revealed that supplementation with metformin, PS, or fermented Polygonatum sibiricum (FPS) lowered the fasting blood glucose, insulin, total cholesterol, triglyceride, and low-density lipoprotein cholesterol of diabetic mice. FPS showed relatively more potency to reduce the homeostasis model assessment-insulin resistance and glycated hemoglobin than PS. Moreover, a high dosage of FPS protected against glucose intolerance and insulin resistance by increasing the ratio of phosphor-AKT/AKT. Histological examination and quantitative polymerase chain reaction results showed that dietary FPS ameliorated the lipid accumulation in liver and white adipose tissue (WAT) by inhibiting lipogenesis, enhancing lipolysis, and fatty acid oxidation. FPS exhibited greater efficacy than PS on improving the transcriptional expression of adipose triacylglyceride lipase, carnitine palmitoyltransferase 1, and uncoupling protein 1. In addition, FPS exerted a striking anti-inflammatory effect by suppressing the expression of interleukin 6, interleukin 1β, tumor necrosis factor-α, and transforming growth factor-β in WAT of diabetic C57BL/6 mice. Finally, FPS supplementation enhanced the activation of AMPK. In conclusion, these results suggest that the FPS may be more promising than PS as a potential therapeutic agent for diabetes and obesity. |
| تدمد: | 1557-7600 1096-620X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::5b2a9f2e137156cb3708b21bad719a01Test https://doi.org/10.1089/jmf.2021.k.0034Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........5b2a9f2e137156cb3708b21bad719a01 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577600 1096620X |
|---|