Novel LRRFIP2‐RAF1 fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with RAF1 fusions and the potential therapeutic implications
| العنوان: | Novel |
|---|---|
| المؤلفون: | Robert E. LeBlanc, Joel A. Lefferts, Michael Baker, Konstantinos Linos |
| المصدر: | Journal of Cutaneous Pathology. 47:1181-1186 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Neuroblastoma RAS viral oncogene homolog, Pathology, medicine.medical_specialty, Histology, business.industry, Molecular pathology, Melanoma, Sentinel lymph node, Dermatology, medicine.disease, Pathology and Forensic Medicine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Acral melanoma, Advanced disease, Cancer research, Medicine, business, neoplasms |
| الوصف: | A small subset of cutaneous melanomas harbor oncogenic gene fusions, which could potentially serve as therapeutic targets for patients with advanced disease as novel therapies are developed. Fusions involving RAF1 are exceedingly rare in melanocytic neoplasms, occurring in less than 1% of melanomas, and usually arise in tumors that are wild type for BRAF, NRAS, and NF1. We describe herein a case of acral melanoma with two satellite metastases and sentinel lymph node involvement. The melanoma had a concomitant KIT variant and LRRFIP2-RAF1 fusion. This constellation of molecular findings has not been reported previously in melanoma. We review the existing literature on melanocytic neoplasms with RAF1 fusions and discuss the potential clinical implications of this genetic event. This article is protected by copyright. All rights reserved. |
| تدمد: | 1600-0560 0303-6987 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4d7bcf414cd5e09d11314f6c76ee6f39Test https://doi.org/10.1111/cup.13817Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........4d7bcf414cd5e09d11314f6c76ee6f39 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000560 03036987 |
|---|