Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia
| العنوان: | Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia |
|---|---|
| المؤلفون: | Jayasri Nanduri, Aaron P. Fox, Nanduri R. Prabhakar, Anna Gridina, Ying-Jie Peng, Benjamin Wang |
| المصدر: | Journal of Neurophysiology. 123:1886-1895 |
| بيانات النشر: | American Physiological Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0303 health sciences, medicine.medical_specialty, Olfactory receptor, Physiology, Chemistry, General Neuroscience, Hypoxic ventilatory response, Hypoxia (medical), 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Glomus cell, Endocrinology, Internal medicine, medicine, Reflex, Carotid body, medicine.symptom, Receptor, 030217 neurology & neurosurgery, 030304 developmental biology, Sensory nerve |
| الوصف: | The role of olfactory receptor 78 (Olfr78) in carotid body (CB) response to hypoxia was examined. BL6 mice with global deletion of Olfr78 manifested an impaired hypoxic ventilatory response (HVR), a hallmark of the CB chemosensory reflex, CB sensory nerve activity, and reduced intracellular Ca2+ concentration ([Ca2+]i) response of glomus cells to hypoxia (Po2 ~ 40 mmHg). In contrast, severe hypoxia (Po2 ~ 10 mmHg) depressed breathing and produced a very weak CB sensory nerve excitation but robust elevation of [Ca2+]i in Olfr78 null glomus cells. CB sensory nerve excitation evoked by Olfr78 ligands, lactate, propionate, acetate, and butyrate were unaffected in mutant mice and were smaller than that evoked by hypoxia (Po2 ~ 40mmHg). Similar results were obtained in Olfr78 null mice on a JAX genetic background. These results demonstrate a role for Olfr78 in CB responses to a wide range of hypoxia, but not severe hypoxia, and do not require either lactate or any other short-chain fatty acids.NEW & NOTEWORTHY The current study demonstrates that olfactory receptor 78 (Olfr78), a G protein-coupled receptor, is an integral component of the hypoxic sensing mechanism of the carotid body to a wide range of low oxygen levels, but not severe hypoxia, and that Olfr78 participation does not require either lactate or any other short-chain fatty acids, proposed ligands of Olfr78. |
| تدمد: | 1522-1598 0022-3077 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::445f96df26767fef5a4e04763f8d773bTest https://doi.org/10.1152/jn.00075.2020Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........445f96df26767fef5a4e04763f8d773b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221598 00223077 |
|---|