Long-Term Consumption of 2-O-β-d -Glucopyranosyl-l -ascorbic Acid from the Fruits of Lycium barbarum Modulates Gut Microbiota in C57BL/6 Mice
| العنوان: | Long-Term Consumption of 2-O-β- |
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| المؤلفون: | Yujia Peng, Wei Dong, Peng Wan, Youlong Cao, Yamei Yan, Xiaoxiong Zeng, Kaiyin Huang |
| المصدر: | Journal of Agricultural and Food Chemistry. 68:8863-8874 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0106 biological sciences, Rikenellaceae, biology, Chemistry, Firmicutes, 010401 analytical chemistry, Lachnospiraceae, Porphyromonadaceae, General Chemistry, Gut flora, biology.organism_classification, Ascorbic acid, 01 natural sciences, 0104 chemical sciences, Food science, General Agricultural and Biological Sciences, Peptococcaceae, 010606 plant biology & botany, Ruminococcaceae |
| الوصف: | The modulating effect of 2-O-β-d-glucopyranosyl-l-ascorbic acid (AA-2βG), a natural derivative of ascorbic acid from the fruits of Lycium barbarum, on mice gut microbiota was investigated in the present study. It was found that AA-2βG was able to adjust the structure of mice gut microbiota, elevated the relative abundances of Verrucomicrobia, Porphyromonadaceae, Verrucomicrobiaceae, and Erysipelotrichaceae, and meanwhile reduced the relative abundances of Firmicutes, Lachnospiraceae, Rikenellaceae, Ruminococcaceae, Bdellovibrionaceae, Anaeroplasmataceae, and Peptococcaceae. Through the linear discriminant analysis effect size analysis, the key microbiota that were found to be significantly changed after long-term consumption of AA-2βG were Ruminococcaceae, Porphyromonadaceae, Lachnospiraceae, and Rikenellaceae. In addition, AA-2βG could upregulate pro-inflammatory cytokines, promote tight junctions between intestinal cells, facilitate the generation of short-chain fatty acids (SCFAs), and upregulate the mRNA expression level of SCFAs receptors, indicating that AA-2βG might promote organism health. The results demonstrated that AA-2βG might maintain organism health by modulating gut microbiota. |
| تدمد: | 1520-5118 0021-8561 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::415884280e5fcb85a98e83c2f80eca80Test https://doi.org/10.1021/acs.jafc.0c04007Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........415884280e5fcb85a98e83c2f80eca80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205118 00218561 |
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