Biochemical and mechanical signals in the lymphatic vasculature
| العنوان: | Biochemical and mechanical signals in the lymphatic vasculature |
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| المؤلفون: | Xin Geng, R. Sathish Srinivasan, Yen-Chun Ho |
| المصدر: | Cellular and Molecular Life Sciences. 78:5903-5923 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, Pathology, medicine.medical_specialty, business.industry, government.form_of_government, Inflammation, Cell Biology, medicine.disease, Review article, Cellular and Molecular Neuroscience, Lymphatic Endothelium, Lymphedema, medicine.anatomical_structure, Lymphatic system, Interstitial fluid, medicine, government, Lymphatic vessel, Molecular Medicine, medicine.symptom, Mechanotransduction, business, Molecular Biology |
| الوصف: | Lymphatic vasculature is an integral part of the cardiovascular system where it maintains interstitial fluid balance. Additionally, lymphatic vasculature regulates lipid assimilation and inflammatory response. Lymphatic vasculature is composed of lymphatic capillaries, collecting lymphatic vessels and valves that function in synergy to absorb and transport fluid against gravitational and pressure gradients. Defects in lymphatic vessels or valves leads to fluid accumulation in tissues (lymphedema), chylous ascites, chylothorax, metabolic disorders and inflammation. The past three decades of research has identified numerous molecules that are necessary for the stepwise development of lymphatic vasculature. However, approaches to treat lymphatic disorders are still limited to massages and compression bandages. Hence, better understanding of the mechanisms that regulate lymphatic vascular development and function is urgently needed to develop efficient therapies. Recent research has linked mechanical signals such as shear stress and matrix stiffness with biochemical pathways that regulate lymphatic vessel growth, patterning and maturation and valve formation. The goal of this review article is to highlight these innovative developments and speculate on unanswered questions. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4138f72dc7c07b5922afea5f8cb7b3c2Test https://doi.org/10.1007/s00018-021-03886-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........4138f72dc7c07b5922afea5f8cb7b3c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
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