Diffusion-based molecular communication (DBMC) systems allow messenger molecules to reach the intended receiver using laws of diffusion. The Brownian motion of messenger molecules introduces delay in the system causing the problem of inter-symbol interference (ISI). Along with ISI, the problem of inter-link interference (ILI) comes into picture in the diffusion-based molecular multiple-input multiple-output (DB-MoMIMO) systems. To combat against ISI and ILI issues, index modulation (IM) approaches are recently proposed in the literature for improving the performance of DB-MoMIMO systems. Despite the existence of IM approaches, problems of ISI and ILI still persist due to the slow random motion of molecules in DB-MoMIMO channels. Motivated by this, a novel coded modulation approach called molecular spatio-temporal coded modulation (MSTCM) is proposed in this paper which shows promising improvement in the performance of DB-MoMIMO systems by encoding the information both in space and time axes. Further, if system has access to two types of molecules, the dual-type modulation schemes are discussed for the same. Moreover, the encoder and decoder designs for the proposed mapping strategy are provided. In addition, a theoretical bit error rate expression for the MSTCM scheme is derived and simulation results are shown to corroborate the theoretical ones.
