Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults
| العنوان: | Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults |
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| المؤلفون: | Katja Pahkala, Jorma Viikari, Terho Lehtimäki, Tuomas O. Kilpeläinen, Anna Viitasalo, Niina Pitkänen, Olli T. Raitakari |
| المصدر: | International Journal of Obesity. 44:848-851 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cardiometabolic risk, Ldl cholesterol, medicine.medical_specialty, Nutrition and Dietetics, Cholesterol, business.industry, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030209 endocrinology & metabolism, Type 2 diabetes, Disease, medicine.disease, Phenotype, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, chemistry, Normal weight, Internal medicine, medicine, 030212 general & internal medicine, business, Body fat distribution |
| الوصف: | Normal weight is associated with a favorable cardiometabolic risk profile and low risk of type 2 diabetes and cardiovascular disease. However, some normal-weight individuals-the "metabolically obese normal weight" (MONW)-show a cardiometabolic risk profile similar to the obese. Previous studies have shown that older age, central body fat distribution, and unfavorable lifestyle increase the risk of MONW. However, the role of early-life factors in MONW remains unknown. We examined the associations of early-life factors with adult MONW in 1178 individuals from the Cardiovascular Risk in Young Finns study who were followed up from childhood to adulthood. The strongest early predictor for adult MONW was an increase in BMI from childhood to adulthood (p = 3.1 × 10-11); each 1 SD increase in BMI z-score from childhood to adulthood led to a 2.56-fold increase in the risk of adult MONW (CI 95% = 1.94-3.38). Other significant predictors of adult MONW were male sex (OR = 2.38, 95% = 1.63-3.47, p = 7.0 × 10-6), higher childhood LDL cholesterol (OR = 1.41 per 1 SD increase in LDL cholesterol, CI 95% = 1.14-1.73, p = 0.001), and lower HDL cholesterol (OR = 1.51 per 1 SD decrease in HDL cholesterol, CI 95% = 1.23-1.85, p = 5.4 × 10-5). Our results suggest that an increase in adiposity from childhood to adulthood is detrimental to cardiometabolic health, even among individuals remaining normal weight. |
| تدمد: | 1476-5497 0307-0565 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::325c2ae303ece303e4a02f17c656cfe5Test https://doi.org/10.1038/s41366-019-0479-9Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........325c2ae303ece303e4a02f17c656cfe5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765497 03070565 |
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