A Systemic Inflammation Response Index (SIRI)-Based Nomogram for Predicting the Recurrence of Early Stage Hepatocellular Carcinoma After Radiofrequency Ablation
| العنوان: | A Systemic Inflammation Response Index (SIRI)-Based Nomogram for Predicting the Recurrence of Early Stage Hepatocellular Carcinoma After Radiofrequency Ablation |
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| المؤلفون: | Yi Chen, Yanan Wang, Xiang Zhou, Yi Yang, Yujing Xin, Xiao Li, Xinyuan Zhang, Ying Li |
| المصدر: | CardioVascular and Interventional Radiology. 45:43-53 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Multivariate analysis, business.industry, Nomogram, Milan criteria, medicine.disease, BCLC Stage, Internal medicine, Hepatocellular carcinoma, Cohort, medicine, Radiology, Nuclear Medicine and imaging, Stage (cooking), Cardiology and Cardiovascular Medicine, business, Survival analysis |
| الوصف: | To explore the prognostic value of the systemic inflammation response index (SIRI) defined as neutrophil count × monocyte count/lymphocyte count in the patients with early stage hepatocellular carcinoma (HCC) within the Milan criteria after radiofrequency ablation (RFA). The prognostic value of SIRI was evaluated in a primary cohort (n = 403) and then further validated in an independent test cohort (n = 140). A novel preoperative prognostic nomogram was constructed from a multivariate analysis and validated in an external validation cohort. The optimal cutoff value of SIRI for patient stratification into a low SIRI group and a high SIRI group was 1.36. Survival analysis showed that the median overall survival (OS) and recurrence-free survival (RFS) were significantly higher in patients with a low SIRI compared to those with a high SIRI. The alpha-fetoprotein (AFP), SIRI, tumor number and size were independent predictors of RFS based on multivariate analysis. The nomogram including the SIRI, tumor number, tumor size, AFP could more accurately determine the prognosis of HCC patients than BCLC stage (0.74 vs. 0.62, P 75% had a better prognosis. Preoperative SIRI was an independent predictor for RFS in patients with early stage HCC within the Milan criteria. The comprehensive nomogram can objectively and reliably help clinicians identify high-risk patients and develop individualized treatment plans. |
| تدمد: | 1432-086X 0174-1551 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::30a3a82bd536b760b2f2bfc51fd9a2e1Test https://doi.org/10.1007/s00270-021-02965-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........30a3a82bd536b760b2f2bfc51fd9a2e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432086X 01741551 |
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