Immunomodulatory activity of biosilica water on mouse dendritic cells
| العنوان: | Immunomodulatory activity of biosilica water on mouse dendritic cells |
|---|---|
| المؤلفون: | Gyung Min Go, You-Jeong Lee, Hong-Gu Joo |
| المصدر: | Journal of the Preventive Veterinary Medicine. 44:156-160 |
| بيانات النشر: | The Korean Society of Preventive Veterinary Medicine, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 010405 organic chemistry, Chemistry, chemical and pharmacologic phenomena, Spleen, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Cell biology, Cell wall, medicine.anatomical_structure, Immune system, Immunity, medicine, 0210 nano-technology, Beta (finance), Metabolic activity, Function (biology), Melosira nummuloides |
| الوصف: | Biosilica is a material extracted from the shell (cell wall) of Melosira nummuloides, a type of sea diatom, and is one of the widely distributed biominerals. Recently, some studies have revealed that biosilica has a characteristic bio-modulatory activity compared to synthetic silica. However, there has been little research on the effects and action mechanisms of biosilica in immune cells. In this study, we investigated the effect of biosilica water on mouse dendritic cells (DCs), the most potent antigen-presenting cells in immunity, and whether it may alter the function of DCs. Biosilica water decreased the metabolic activity of DCs at 20% concentration (v/v) and the production of IL-1 beta in a concentration-dependent manner. And also, more cells with fragmented nuclei were observed in the DCs treated with 20% biosilica water compared to other treatment groups. The mixed leukocyte response experiment showed the biosilica water-treated DCs significantly modulated the metabolic activity and proliferation of allogeneic spleen cells compared to control DCs. This result suggests that biosilica water may modulate the antigen-presenting capability of DCs. Taken together, this study shows the immunomodulatory activity of biosilica on DCs and may affect immune responses. Further research is needed to investigate the immunological activity of biosilica water. |
| تدمد: | 2287-8009 2287-7991 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::28ad977892cf4fe96d0594bd5d29317bTest https://doi.org/10.13041/jpvm.2020.44.4.156Test |
| رقم الانضمام: | edsair.doi...........28ad977892cf4fe96d0594bd5d29317b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22878009 22877991 |
|---|