Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres
| العنوان: | Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres |
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| المؤلفون: | Maria A. Oquendo, Christos Davatzikos, Darsol Seok, Kristin A. Linn, Myrna M. Weissman, Nicholas C. Cullen, Yvette I. Sheline, Meichen Yu, Romain Duprat, Desmond J. Oathes, Irem Aselcioglu, Philip A. Cook, Tyler M. Moore, Russell T. Shinohara |
| المصدر: | Molecular Psychiatry. 26:2764-2775 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cingulate cortex, business.industry, Precuneus, Anhedonia, medicine.disease, Neuroticism, 03 medical and health sciences, Cellular and Molecular Neuroscience, Psychiatry and Mental health, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Frontal lobe, Sexual abuse, medicine, Major depressive disorder, medicine.symptom, Big Five personality traits, business, Molecular Biology, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Abnormalities in brain structural measures, such as cortical thickness and subcortical volumes, are observed in patients with major depressive disorder (MDD) who also often show heterogeneous clinical features. This study seeks to identify the multivariate associations between structural phenotypes and specific clinical symptoms, a novel area of investigation. T1-weighted magnetic resonance imaging measures were obtained using 3 T scanners for 178 unmedicated depressed patients at four academic medical centres. Cortical thickness and subcortical volumes were determined for the depressed patients and patients' clinical presentation was characterized by 213 item-level clinical measures, which were grouped into several large, homogeneous categories by K-means clustering. The multivariate correlations between structural and cluster-level clinical-feature measures were examined using canonical correlation analysis (CCA) and confirmed with both 5-fold and leave-one-site-out cross-validation. Four broad types of clinical measures were detected based on clustering: an anxious misery composite (composed of item-level depression, anxiety, anhedonia, neuroticism and suicidality scores); positive personality traits (extraversion, openness, agreeableness and conscientiousness); reported history of physical/emotional trauma; and a reported history of sexual abuse. Responses on the item-level anxious misery measures were negatively associated with cortical thickness/subcortical volumes in the limbic system and frontal lobe; reported childhood history of physical/emotional trauma and sexual abuse measures were negatively correlated with entorhinal thickness and left hippocampal volume, respectively. In contrast, the positive traits measures were positively associated with hippocampal and amygdala volumes and cortical thickness of the highly-connected precuneus and cingulate cortex. Our findings suggest that structural brain measures may reflect neurobiological mechanisms underlying MDD features. |
| تدمد: | 1476-5578 1359-4184 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::25152a2e075ad8f840fec637c056a143Test https://doi.org/10.1038/s41380-021-01039-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........25152a2e075ad8f840fec637c056a143 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765578 13594184 |
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